Gene description for Ctse
Gene name cathepsin E
Gene symbol Ctse
Other names/aliases A430072O03Rik
C920004C08Rik
CE
CatE
Species Mus musculus
 Database cross references - Ctse
ExoCarta ExoCarta_13034
Vesiclepedia VP_13034
Entrez Gene 13034
UniProt P70269  
 Ctse identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ctse
Molecular Function
    aspartic-type endopeptidase activity GO:0004190 IBA
    aspartic-type endopeptidase activity GO:0004190 IDA
    aspartic-type endopeptidase activity GO:0004190 ISO
    peptidase activity GO:0008233 ISO
    identical protein binding GO:0042802 IPI
Biological Process
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 ISO
    protein autoprocessing GO:0016540 IEA
    protein autoprocessing GO:0016540 ISO
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IBA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IDA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 ISO
Subcellular Localization
    endosome GO:0005768 IBA
    endosome GO:0005768 IDA
    endosome GO:0005768 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Ctse in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ctse
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ctse is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Immune System IEA Reactome
MHC class II antigen presentation IEA Reactome





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