Gene description for Vcan
Gene name versican
Gene symbol Vcan
Other names/aliases 5430420N07Rik
9430051N09
Cspg2
DPEAAE
NG2
PG-M
PG-M(V0)
PG-M(V1)
hdf
Species Mus musculus
 Database cross references - Vcan
ExoCarta ExoCarta_13003
Vesiclepedia VP_13003
Entrez Gene 13003
 Vcan identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Vcan
Molecular Function
    calcium ion binding GO:0005509 IEA
    hyaluronic acid binding GO:0005540 IEA
    protein phosphatase binding GO:0019903 IPI
    extracellular matrix structural constituent conferring compression resistance GO:0030021 RCA
    carbohydrate binding GO:0030246 IEA
Biological Process
    skeletal system development GO:0001501 IBA
    ureteric bud development GO:0001657 IEP
    cell adhesion GO:0007155 IEA
    central nervous system development GO:0007417 IBA
    heart development GO:0007507 IMP
    glial cell migration GO:0008347 ISO
Subcellular Localization
    photoreceptor outer segment GO:0001750 IEA
    extracellular region GO:0005576 ISO
    extracellular region GO:0005576 ISS
    extracellular space GO:0005615 IBA
    cell surface GO:0009986 ISO
    extracellular matrix GO:0031012 IDA
    interphotoreceptor matrix GO:0033165 IEA
    synapse GO:0045202 IBA
    synapse GO:0045202 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 ISO
    perineuronal net GO:0072534 IBA
    perineuronal net GO:0072534 ISO
 Experiment description of studies that identified Vcan in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Vcan
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Vcan is involved
No pathways found





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