Gene description for Cpa3
Gene name carboxypeptidase A3, mast cell
Gene symbol Cpa3
Other names/aliases MC-CPA
mMC-CPA
Species Mus musculus
 Database cross references - Cpa3
ExoCarta ExoCarta_12873
Vesiclepedia VP_12873
Entrez Gene 12873
UniProt P15089  
 Cpa3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cpa3
Molecular Function
    metallocarboxypeptidase activity GO:0004181 IBA
    metallocarboxypeptidase activity GO:0004181 IEA
    metallocarboxypeptidase activity GO:0004181 IMP
    metallocarboxypeptidase activity GO:0004181 ISO
    peptidase activity GO:0008233 IDA
    zinc ion binding GO:0008270 IEA
Biological Process
    regulation of angiotensin levels in blood GO:0002002 IGI
    angiotensin maturation GO:0002003 IMP
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IEA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular space GO:0005615 IBA
    transport vesicle GO:0030133 IEA
 Experiment description of studies that identified Cpa3 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cpa3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cpb2  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Cpa3 is involved
PathwayEvidenceSource
Metabolism of Angiotensinogen to Angiotensins IEA Reactome
Metabolism of proteins IEA Reactome
Peptide hormone metabolism IEA Reactome





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