Gene description for Cdh13
Gene name cadherin 13
Gene symbol Cdh13
Other names/aliases 4932416G01Rik
Cdht
T-cadherin
Tcad
Species Mus musculus
 Database cross references - Cdh13
ExoCarta ExoCarta_12554
Vesiclepedia VP_12554
Entrez Gene 12554
UniProt Q9WTR5  
 Cdh13 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cdh13
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IBA
    low-density lipoprotein particle binding GO:0030169 IEA
    low-density lipoprotein particle binding GO:0030169 ISO
    identical protein binding GO:0042802 IPI
    cadherin binding GO:0045296 IBA
    cadherin binding GO:0045296 IEA
    cadherin binding GO:0045296 ISO
    adiponectin binding GO:0055100 IDA
    lipoprotein particle binding GO:0071813 ISO
Biological Process
    cell morphogenesis GO:0000902 IBA
    positive regulation of endothelial cell proliferation GO:0001938 IEA
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    positive regulation of cell-matrix adhesion GO:0001954 IEA
    positive regulation of cell-matrix adhesion GO:0001954 ISO
    sprouting angiogenesis GO:0002040 IEA
    sprouting angiogenesis GO:0002040 ISO
    cell-cell junction assembly GO:0007043 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 ISO
    negative regulation of cell adhesion GO:0007162 IEA
    negative regulation of cell adhesion GO:0007162 ISO
    Rho protein signal transduction GO:0007266 IEA
    Rho protein signal transduction GO:0007266 ISO
    negative regulation of cell population proliferation GO:0008285 IEA
    negative regulation of cell population proliferation GO:0008285 ISO
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 IBA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 IEA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 ISO
    cell migration GO:0016477 IBA
    Rac protein signal transduction GO:0016601 IEA
    Rac protein signal transduction GO:0016601 ISO
    lamellipodium assembly GO:0030032 IEA
    lamellipodium assembly GO:0030032 ISO
    regulation of endocytosis GO:0030100 IEA
    regulation of endocytosis GO:0030100 ISO
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    adherens junction organization GO:0034332 IBA
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 IEA
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 ISO
    endothelial cell migration GO:0043542 IEA
    endothelial cell migration GO:0043542 ISO
    keratinocyte proliferation GO:0043616 IEA
    keratinocyte proliferation GO:0043616 ISO
    cell-cell adhesion mediated by cadherin GO:0044331 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    positive regulation of smooth muscle cell proliferation GO:0048661 ISO
    positive regulation of calcium-mediated signaling GO:0050850 IEA
    positive regulation of calcium-mediated signaling GO:0050850 ISO
    positive regulation of positive chemotaxis GO:0050927 IEA
    positive regulation of positive chemotaxis GO:0050927 ISO
    localization within membrane GO:0051668 IEA
    localization within membrane GO:0051668 ISO
    low-density lipoprotein particle mediated signaling GO:0055096 IEA
    low-density lipoprotein particle mediated signaling GO:0055096 ISO
Subcellular Localization
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    caveola GO:0005901 IEA
    caveola GO:0005901 ISO
    adherens junction GO:0005912 IBA
    external side of plasma membrane GO:0009897 IDA
    catenin complex GO:0016342 IBA
    neuron projection GO:0043005 IEA
    neuron projection GO:0043005 ISO
    synapse GO:0045202 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    GABA-ergic synapse GO:0098982 IEA
    GABA-ergic synapse GO:0098982 ISO
 Experiment description of studies that identified Cdh13 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cdh13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Htt  
Affinity Capture-MS Mus musculus
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