Gene description for Cd84
Gene name CD84 antigen
Gene symbol Cd84
Other names/aliases A130013D22Rik
CDw84
SLAMF5
Species Mus musculus
 Database cross references - Cd84
ExoCarta ExoCarta_12523
Vesiclepedia VP_12523
Entrez Gene 12523
UniProt Q18PI6  
 Cd84 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cd84
Molecular Function
    identical protein binding GO:0042802 ISO
Biological Process
    adaptive immune response GO:0002250 IEA
    autophagy GO:0006914 IEA
    immune response GO:0006955 IBA
    cell adhesion GO:0007155 IEA
    regulation of lipopolysaccharide-mediated signaling pathway GO:0031664 IDA
    negative regulation of granulocyte macrophage colony-stimulating factor production GO:0032685 ISO
    negative regulation of interleukin-10 production GO:0032693 IDA
    negative regulation of interleukin-18 production GO:0032701 ISO
    negative regulation of interleukin-6 production GO:0032715 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    negative regulation of mast cell activation GO:0033004 ISO
    T cell activation GO:0042110 IBA
    regulation of macrophage activation GO:0043030 IDA
    negative regulation of mast cell degranulation GO:0043305 ISO
    positive regulation of MAPK cascade GO:0043410 IDA
    innate immune response GO:0045087 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    positive regulation of monocyte chemotactic protein-1 production GO:0071639 IDA
    regulation of store-operated calcium entry GO:2001256 ISO
Subcellular Localization
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IBA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Cd84 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cd84
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd84 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall IEA Reactome
Hemostasis IEA Reactome





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