Gene description for Cav1
Gene name caveolin 1, caveolae protein
Gene symbol Cav1
Other names/aliases Cav
Cav-1
Species Mus musculus
 Database cross references - Cav1
ExoCarta ExoCarta_12389
Vesiclepedia VP_12389
Entrez Gene 12389
UniProt P49817  
 Cav1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cav1
Molecular Function
    SNARE binding GO:0000149 ISO
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    oxysterol binding GO:0008142 IMP
    peptidase activator activity GO:0016504 IMP
    enzyme binding GO:0019899 ISO
    kinase binding GO:0019900 ISO
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IPI
    protein kinase binding GO:0019901 ISO
    syntaxin binding GO:0019905 ISO
    protein tyrosine kinase inhibitor activity GO:0030292 IMP
    protein-macromolecule adaptor activity GO:0030674 IDA
    small GTPase binding GO:0031267 IEA
    small GTPase binding GO:0031267 ISO
    receptor serine/threonine kinase binding GO:0033612 ISO
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    transmembrane transporter binding GO:0044325 IBA
    transmembrane transporter binding GO:0044325 IEA
    transmembrane transporter binding GO:0044325 ISO
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
    protein heterodimerization activity GO:0046982 IPI
    nitric-oxide synthase binding GO:0050998 IPI
    nitric-oxide synthase binding GO:0050998 ISO
    ATPase binding GO:0051117 IEA
    ATPase binding GO:0051117 ISO
    molecular adaptor activity GO:0060090 IBA
    molecular adaptor activity GO:0060090 IDA
    inward rectifier potassium channel inhibitor activity GO:0070320 IEA
    inward rectifier potassium channel inhibitor activity GO:0070320 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    MAPK cascade GO:0000165 IMP
    angiogenesis GO:0001525 IGI
    vasculogenesis GO:0001570 IMP
    response to hypoxia GO:0001666 IMP
    endothelial cell proliferation GO:0001935 IMP
    negative regulation of endothelial cell proliferation GO:0001937 IBA
    negative regulation of endothelial cell proliferation GO:0001937 IMP
    negative regulation of endothelial cell proliferation GO:0001937 ISO
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    negative regulation of cytokine-mediated signaling pathway GO:0001960 IMP
    regulation of the force of heart contraction GO:0002026 IMP
    glandular epithelial cell differentiation GO:0002067 IMP
    response to ischemia GO:0002931 IMP
    regulation of the force of heart contraction by chemical signal GO:0003057 IGI
    triglyceride metabolic process GO:0006641 IMP
    nitric oxide biosynthetic process GO:0006809 IMP
    calcium ion transport GO:0006816 IMP
    intracellular calcium ion homeostasis GO:0006874 IMP
    intracellular calcium ion homeostasis GO:0006874 ISO
    endocytosis GO:0006897 TAS
    regulation of smooth muscle contraction GO:0006940 IMP
    tyrosine phosphorylation of STAT protein GO:0007260 IMP
    skeletal muscle tissue development GO:0007519 IMP
    lactation GO:0007595 IMP
    protein localization GO:0008104 IMP
    cell population proliferation GO:0008283 IMP
    negative regulation of cell population proliferation GO:0008285 IMP
    response to mechanical stimulus GO:0009612 ISO
    response to bacterium GO:0009617 IEA
    response to bacterium GO:0009617 ISO
    positive regulation of signal transduction GO:0009967 ISO
    negative regulation of signal transduction GO:0009968 IDA
    positive regulation of calcium ion transport into cytosol GO:0010524 IDA
    post-transcriptional regulation of gene expression GO:0010608 IMP
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of muscle cell apoptotic process GO:0010656 ISO
    positive regulation of cholesterol efflux GO:0010875 IEA
    positive regulation of cholesterol efflux GO:0010875 ISO
    negative regulation of smooth muscle cell migration GO:0014912 ISO
    protein transport GO:0015031 IMP
    receptor-mediated endocytosis of virus by host cell GO:0019065 IEA
    receptor-mediated endocytosis of virus by host cell GO:0019065 ISO
    regulation of fatty acid metabolic process GO:0019217 IMP
    cytokine-mediated signaling pathway GO:0019221 IMP
    lipid storage GO:0019915 IMP
    cell differentiation GO:0030154 IBA
    regulation of blood coagulation GO:0030193 IEA
    regulation of blood coagulation GO:0030193 ISO
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    negative regulation of BMP signaling pathway GO:0030514 ISO
    negative regulation of epithelial cell differentiation GO:0030857 IMP
    mammary gland development GO:0030879 IMP
    positive regulation of microtubule polymerization GO:0031116 ISO
    T cell costimulation GO:0031295 ISO
    T cell costimulation GO:0031295 ISS
    negative regulation of protein ubiquitination GO:0031397 IMP
    negative regulation of protein ubiquitination GO:0031397 ISO
    positive regulation of protein ubiquitination GO:0031398 IEA
    positive regulation of protein ubiquitination GO:0031398 ISO
    receptor internalization GO:0031623 ISO
    receptor internalization GO:0031623 ISS
    maintenance of protein location in cell GO:0032507 ISO
    response to progesterone GO:0032570 ISO
    negative regulation of peptidyl-serine phosphorylation GO:0033137 ISO
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    cholesterol efflux GO:0033344 ISO
    intracellular nitric oxide homeostasis GO:0033484 IMP
    positive regulation of toll-like receptor 3 signaling pathway GO:0034141 IEA
    positive regulation of toll-like receptor 3 signaling pathway GO:0034141 ISO
    insulin receptor internalization GO:0038016 IMP
    angiotensin-activated signaling pathway GO:0038166 IGI
    vasoconstriction GO:0042310 IMP
    negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 IDA
    negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 IMP
    cholesterol homeostasis GO:0042632 IMP
    positive regulation of catalytic activity GO:0043085 IMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    negative regulation of MAP kinase activity GO:0043407 IMP
    negative regulation of MAPK cascade GO:0043409 IMP
    response to estrogen GO:0043627 IDA
    response to estrogen GO:0043627 ISO
    negative regulation of nitric oxide biosynthetic process GO:0045019 IMP
    negative regulation of neuron differentiation GO:0045665 ISO
    positive regulation of endocytosis GO:0045807 ISO
    positive regulation of vasoconstriction GO:0045907 IMP
    positive regulation of vasoconstriction GO:0045907 ISO
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IDA
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IGI
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IMP
    muscle cell cellular homeostasis GO:0046716 IMP
    microtubule polymerization GO:0046785 ISO
    fibroblast proliferation GO:0048144 IMP
    negative regulation of fibroblast proliferation GO:0048147 IMP
    negative regulation of pinocytosis GO:0048550 IEA
    negative regulation of pinocytosis GO:0048550 ISO
    negative regulation of smooth muscle cell proliferation GO:0048662 ISO
    negative regulation of nitric-oxide synthase activity GO:0051001 IMP
    regulation of cytosolic calcium ion concentration GO:0051480 IBA
    regulation of cytosolic calcium ion concentration GO:0051480 IEA
    regulation of cytosolic calcium ion concentration GO:0051480 ISO
    response to calcium ion GO:0051592 IDA
    establishment of localization in cell GO:0051649 IMP
    membrane depolarization GO:0051899 IMP
    regulation of peptidase activity GO:0052547 IMP
    calcium ion homeostasis GO:0055074 IMP
    mammary gland involution GO:0060056 IMP
    canonical Wnt signaling pathway GO:0060070 IEA
    canonical Wnt signaling pathway GO:0060070 ISO
    positive regulation of cell adhesion molecule production GO:0060355 IEA
    positive regulation of cell adhesion molecule production GO:0060355 ISO
    negative regulation of necroptotic process GO:0060546 IMP
    negative regulation of protein tyrosine kinase activity GO:0061099 ISO
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO
    caveola assembly GO:0070836 IBA
    caveola assembly GO:0070836 IDA
    caveola assembly GO:0070836 IGI
    caveola assembly GO:0070836 IMP
    caveola assembly GO:0070836 ISO
    cellular response to misfolded protein GO:0071218 IEA
    cellular response to misfolded protein GO:0071218 ISO
    cellular response to mechanical stimulus GO:0071260 ISO
    cellular response to exogenous dsRNA GO:0071360 IEA
    cellular response to exogenous dsRNA GO:0071360 ISO
    cellular response to peptide hormone stimulus GO:0071375 IGI
    cellular response to hyperoxia GO:0071455 IEA
    cellular response to hyperoxia GO:0071455 ISO
    cellular response to transforming growth factor beta stimulus GO:0071560 IMP
    basement membrane organization GO:0071711 IMP
    caveolin-mediated endocytosis GO:0072584 IMP
    caveolin-mediated endocytosis GO:0072584 ISO
    regulation of heart rate by cardiac conduction GO:0086091 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    cellular senescence GO:0090398 ISO
    apoptotic signaling pathway GO:0097190 IEA
    apoptotic signaling pathway GO:0097190 ISO
    regulation of membrane repolarization during action potential GO:0098903 IEA
    regulation of membrane repolarization during action potential GO:0098903 ISO
    regulation of ventricular cardiac muscle cell action potential GO:0098911 IMP
    positive regulation of cold-induced thermogenesis GO:0120162 IMP
    regulation of ruffle assembly GO:1900027 IEA
    regulation of ruffle assembly GO:1900027 ISO
    negative regulation of peptidyl-tyrosine autophosphorylation GO:1900085 ISO
    negative regulation of potassium ion transmembrane transport GO:1901380 IEA
    negative regulation of potassium ion transmembrane transport GO:1901380 ISO
    regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 IMP
    positive regulation of gap junction assembly GO:1903598 IMP
    negative regulation of inward rectifier potassium channel activity GO:1903609 ISO
    positive regulation of ERAD pathway GO:1904294 IEA
    positive regulation of ERAD pathway GO:1904294 ISO
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 ISO
    negative regulation of calcium ion import across plasma membrane GO:1905949 ISO
    regulation of entry of bacterium into host cell GO:2000535 IEA
    regulation of entry of bacterium into host cell GO:2000535 ISO
    negative regulation of anoikis GO:2000811 IMP
    negative regulation of anoikis GO:2000811 ISO
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IEA
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 ISO
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IEA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    acrosomal membrane GO:0002080 IDA
    caveolar macromolecular signaling complex GO:0002095 IDA
    endosome GO:0005768 ISO
    endosome GO:0005768 ISS
    peroxisomal membrane GO:0005778 ISO
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISO
    lipid droplet GO:0005811 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    caveola GO:0005901 IDA
    caveola GO:0005901 ISO
    caveola GO:0005901 ISS
    caveola GO:0005901 TAS
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 IDA
    focal adhesion GO:0005925 ISO
    focal adhesion GO:0005925 ISO
    cilium GO:0005929 IDA
    cell cortex GO:0005938 IDA
    basal plasma membrane GO:0009925 ISO
    cell surface GO:0009986 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 ISO
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 ISO
    protein-containing complex GO:0032991 IDA
    protein-containing complex GO:0032991 IPI
    protein-containing complex GO:0032991 ISO
    sarcolemma GO:0042383 IBA
    membrane raft GO:0045121 IDA
    membrane raft GO:0045121 ISO
    perinuclear region of cytoplasm GO:0048471 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Cav1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cav1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Flot1 14251
Co-fractionation Mus musculus
2 Adcy3  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
3 Stoml3  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
4 Jak2 16452
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
5 Atg5  
Affinity Capture-RNA Mus musculus
6 Insr  
Co-fractionation Mus musculus
7 Pparg  
Affinity Capture-Western Mus musculus
8 Park2  
Affinity Capture-Western Mus musculus
Co-localization Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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