Gene description for Capn6
Gene name calpain 6
Gene symbol Capn6
Other names/aliases -
Species Mus musculus
 Database cross references - Capn6
ExoCarta ExoCarta_12338
Vesiclepedia VP_12338
Entrez Gene 12338
UniProt O35646  
 Capn6 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Capn6
Molecular Function
    calcium-dependent cysteine-type endopeptidase activity GO:0004198 IBA
    calcium-dependent cysteine-type endopeptidase activity GO:0004198 IEA
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IDA
Biological Process
    microtubule bundle formation GO:0001578 IMP
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IEA
    regulation of cytoskeleton organization GO:0051493 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    microtubule GO:0005874 IDA
    spindle microtubule GO:0005876 IEA
    spindle microtubule GO:0005876 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Capn6 in sEVs
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Capn6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Capn3  
Co-fractionation Mus musculus
2 Capn12  
Co-fractionation Mus musculus
3 Capn5  
Co-fractionation Mus musculus
4 Abhd17c  
Co-fractionation Mus musculus
5 Eed  
Affinity Capture-MS Mus musculus
6 Micu1  
Co-fractionation Mus musculus
7 Fancd2  
Affinity Capture-MS Mus musculus
8 Cyp4f18  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Capn6 is involved
PathwayEvidenceSource
Degradation of the extracellular matrix IEA Reactome
Extracellular matrix organization IEA Reactome





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