Gene description for CCR4
Gene name chemokine (C-C motif) receptor 4
Gene symbol CCR4
Other names/aliases CC-CKR-4
CD194
CKR4
CMKBR4
ChemR13
HGCN:14099
K5-5
Species Homo sapiens
 Database cross references - CCR4
ExoCarta ExoCarta_1233
Vesiclepedia VP_1233
Entrez Gene 1233
HGNC 1605
MIM 604836
UniProt P51679  
 CCR4 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CCR4
Molecular Function
    chemokine receptor activity GO:0004950 TAS
    protein binding GO:0005515 IPI
    C-C chemokine receptor activity GO:0016493 IBA
    C-C chemokine binding GO:0019957 IBA
Biological Process
    tolerance induction GO:0002507 IEA
    chemotaxis GO:0006935 TAS
    inflammatory response GO:0006954 IEA
    immune response GO:0006955 IBA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IBA
    response to bacterium GO:0009617 IEA
    calcium-mediated signaling GO:0019722 IBA
    homeostasis of number of cells GO:0048872 IEA
    positive regulation of positive chemotaxis GO:0050927 IEA
    cell chemotaxis GO:0060326 IBA
    chemokine-mediated signaling pathway GO:0070098 IEA
    interneuron migration GO:1904936 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    neuronal cell body GO:0043025 IEA
 Experiment description of studies that identified CCR4 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CCR4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Affinity Capture-Western Homo sapiens
2 CCL3  
Reconstituted Complex Homo sapiens
3 FXR2 9513
Two-hybrid Homo sapiens
4 CCL22 6367
Reconstituted Complex Homo sapiens
5 SYNGR2 9144
Two-hybrid Homo sapiens
6 CCKBR  
Two-hybrid Homo sapiens
7 NAT14 57106
Two-hybrid Homo sapiens
8 DHCR24 1718
Two-hybrid Homo sapiens
9 CLASP2 23122
Two-hybrid Homo sapiens
10 PKM 5315
Two-hybrid Homo sapiens
11 BSG 682
Two-hybrid Homo sapiens
12 TUSC5  
Two-hybrid Homo sapiens
13 CNTNAP1 8506
Two-hybrid Homo sapiens
14 NSUN2 54888
Two-hybrid Homo sapiens
15 CLPTM1 1209
Two-hybrid Homo sapiens
16 ERGIC3 51614
Two-hybrid Homo sapiens
17 ZNF335 63925
Affinity Capture-Western Homo sapiens
18 TMEM11 8834
Two-hybrid Homo sapiens
19 GHITM 27069
Two-hybrid Homo sapiens
20 RTN4 57142
Two-hybrid Homo sapiens
21 PTOV1  
Two-hybrid Homo sapiens
22 CACNA1H  
Two-hybrid Homo sapiens
23 NDRG2 57447
Two-hybrid Homo sapiens
24 CCL5 6352
Reconstituted Complex Homo sapiens
25 SLCO4A1 28231
Two-hybrid Homo sapiens
26 CH25H  
Two-hybrid Homo sapiens
27 SLC3A2 6520
Two-hybrid Homo sapiens
28 PRDX1 5052
Two-hybrid Homo sapiens
29 SLC12A5 57468
Two-hybrid Homo sapiens
30 TMEM101  
Two-hybrid Homo sapiens
31 B3GAT3 26229
Two-hybrid Homo sapiens
32 TMEM110  
Two-hybrid Homo sapiens
33 ATP2A2 488
Two-hybrid Homo sapiens
34 CDK10  
Two-hybrid Homo sapiens
35 RTN1 6252
Two-hybrid Homo sapiens
36 ADRBK2  
Affinity Capture-Western Homo sapiens
37 ITFG3 83986
Two-hybrid Homo sapiens
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