Gene description for Cab39
Gene name calcium binding protein 39
Gene symbol Cab39
Other names/aliases AA408805
AA960512
C78372
MO25
MO25alpha
Species Mus musculus
 Database cross references - Cab39
ExoCarta ExoCarta_12283
Vesiclepedia VP_12283
Entrez Gene 12283
UniProt Q06138  
 Cab39 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cab39
Molecular Function
    calcium ion binding GO:0005509 ISS
    kinase binding GO:0019900 IEA
    kinase binding GO:0019900 ISO
    protein kinase activator activity GO:0030295 ISO
    protein kinase activator activity GO:0030295 ISS
    protein serine/threonine kinase activator activity GO:0043539 IBA
    protein serine/threonine kinase activator activity GO:0043539 IEA
    protein serine/threonine kinase activator activity GO:0043539 ISO
Biological Process
    signal transduction GO:0007165 ISO
    positive regulation of peptidyl-threonine phosphorylation GO:0010800 ISO
    response to activity GO:0014823 IEA
    peptidyl-serine phosphorylation GO:0018105 ISO
    activation of protein kinase activity GO:0032147 IDA
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 IEA
    intracellular signal transduction GO:0035556 ISO
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    response to thyroid hormone GO:0097066 IEA
Subcellular Localization
    cytoplasm GO:0005737 IC
    cytoplasm GO:0005737 ISO
    Z disc GO:0030018 IEA
    Z disc GO:0030018 ISO
    protein-containing complex GO:0032991 ISO
    serine/threonine protein kinase complex GO:1902554 IEA
    serine/threonine protein kinase complex GO:1902554 ISO
 Experiment description of studies that identified Cab39 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cab39
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Stk26  
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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