Gene description for C5ar1
Gene name	complement component 5a receptor 1
Gene symbol	C5ar1
Other names/aliases	C5aR C5r1 Cd88 D7Msu1
Species	Mus musculus
Database cross references - C5ar1
ExoCarta	ExoCarta_12273
Vesiclepedia	VP_12273
Entrez Gene	12273
UniProt	P30993
C5ar1 identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for C5ar1

Molecular Function     complement component C5a binding GO:0001856 ISO     complement component C5a receptor activity GO:0004878 IBA     complement component C5a receptor activity GO:0004878 IDA     complement component C5a receptor activity GO:0004878 ISO     complement component C5a receptor activity GO:0004878 ISS     G protein-coupled receptor activity GO:0004930 IBA     G protein-coupled receptor activity GO:0004930 IEA     G protein-coupled receptor activity GO:0004930 ISO Biological Process     microglial cell activation GO:0001774 IGI     complement receptor mediated signaling pathway GO:0002430 IBA     inflammatory response GO:0006954 IBA     G protein-coupled receptor signaling pathway GO:0007186 IDA     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IBA     positive regulation of cytosolic calcium ion concentration GO:0007204 IBA     positive regulation of cytosolic calcium ion concentration GO:0007204 ISO     positive regulation of vascular endothelial growth factor production GO:0010575 IMP     positive regulation of macrophage chemotaxis GO:0010759 IMP     cell proliferation in hindbrain GO:0021534 ISO     neutrophil chemotaxis GO:0030593 IMP     response to peptidoglycan GO:0032494 IMP     complement component C5a signaling pathway GO:0038178 IEA     complement component C5a signaling pathway GO:0038178 ISO     mRNA transcription by RNA polymerase II GO:0042789 ISO     mRNA transcription by RNA polymerase II GO:0042789 ISS     negative regulation of neuron apoptotic process GO:0043524 ISO     positive regulation of angiogenesis GO:0045766 IMP     astrocyte activation GO:0048143 IGI     positive regulation of epithelial cell proliferation GO:0050679 ISO     positive regulation of epithelial cell proliferation GO:0050679 ISS     defense response to Gram-positive bacterium GO:0050830 IMP     cognition GO:0050890 IGI     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     positive regulation of neutrophil chemotaxis GO:0090023 IMP     amyloid-beta clearance GO:0097242 IGI     presynapse organization GO:0099172 IGI Subcellular Localization     plasma membrane GO:0005886 IBA     cell surface GO:0009986 ISO     basolateral plasma membrane GO:0016323 ISO     basolateral plasma membrane GO:0016323 ISS     cytoplasmic vesicle GO:0031410 IEA     apical part of cell GO:0045177 ISO     apical part of cell GO:0045177 ISS