Gene description for Serpinc1
Gene name serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
Gene symbol Serpinc1
Other names/aliases AI114908
ATIII
At-3
At3
Species Mus musculus
 Database cross references - Serpinc1
ExoCarta ExoCarta_11905
Entrez Gene 11905
UniProt P32261  
 Serpinc1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Serpinc1
Molecular Function
    heparin binding GO:0008201 ISO
    serine-type endopeptidase inhibitor activity GO:0004867 ISO
    peptidase inhibitor activity GO:0030414 IEA
    protease binding GO:0002020 ISO
Biological Process
    negative regulation of inflammatory response GO:0050728 ISO
    response to nutrient GO:0007584 ISO
    blood coagulation GO:0007596 IEA
    negative regulation of peptidase activity GO:0010466 IEA
    regulation of blood coagulation, intrinsic pathway GO:2000266 IEA
    negative regulation of endopeptidase activity GO:0010951 ISO
    hemostasis GO:0007599 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
    blood microparticle GO:0072562 ISO
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Serpinc1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Serpinc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Serpinc1 is involved
PathwayEvidenceSource
Common Pathway of Fibrin Clot Formation IEA Reactome
Intrinsic Pathway of Fibrin Clot Formation IEA Reactome





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