Gene description for Acsl6
Gene name acyl-CoA synthetase long-chain family member 6
Gene symbol Acsl6
Other names/aliases Facl6
Lacsl
Species Rattus norvegicus
 Database cross references - Acsl6
ExoCarta ExoCarta_117243
Entrez Gene 117243
UniProt P33124  
 Acsl6 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Acsl6
Molecular Function
    ATP binding GO:0005524 IEA
    protein homodimerization activity GO:0042803 ISO
    catalytic activity GO:0003824 IEA
    long-chain fatty acid-CoA ligase activity GO:0004467 ISO
    enzyme binding GO:0019899 ISO
Biological Process
    cellular response to insulin stimulus GO:0032869 IEP
    phospholipid biosynthetic process GO:0008654 IMP
    neuron development GO:0048666 IEP
    response to nutrient GO:0007584 IEP
    metabolic process GO:0008152 IEA
    positive regulation of neuron projection development GO:0010976 IMP
    response to steroid hormone GO:0048545 IEP
    response to gravity GO:0009629 IEP
    triglyceride metabolic process GO:0006641 IGI
    neuroblast proliferation GO:0007405 ISO
    response to hypoxia GO:0001666 IEP
    fatty acid transport GO:0015908 IGI
    positive regulation of plasma membrane long-chain fatty acid transport GO:0010747 IMP
    long-chain fatty acid metabolic process GO:0001676 ISO
    positive regulation of triglyceride biosynthetic process GO:0010867 IGI
Subcellular Localization
    nucleus GO:0005634 IDA
    integral component of membrane GO:0016021 IEA
    mitochondrial outer membrane GO:0005741 IEA
    peroxisomal membrane GO:0005778 IEA
    membrane GO:0016020 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Acsl6 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Acsl6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acsl6 is involved
PathwayEvidenceSource
Synthesis of very long-chain fatty acyl-CoAs IEA Reactome





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