Gene description for Acsl6
Gene name acyl-CoA synthetase long-chain family member 6
Gene symbol Acsl6
Other names/aliases Facl6
Lacsl
Species Rattus norvegicus
 Database cross references - Acsl6
ExoCarta ExoCarta_117243
Vesiclepedia VP_117243
Entrez Gene 117243
UniProt P33124  
 Acsl6 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Acsl6
Molecular Function
    long-chain fatty acid-CoA ligase activity GO:0004467 IDA
    long-chain fatty acid-CoA ligase activity GO:0004467 IEA
    long-chain fatty acid-CoA ligase activity GO:0004467 ISO
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 ISO
    protein homodimerization activity GO:0042803 IDA
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    arachidonate-CoA ligase activity GO:0047676 IBA
    arachidonate-CoA ligase activity GO:0047676 IDA
Biological Process
    very long-chain fatty acid metabolic process GO:0000038 IBA
    response to hypoxia GO:0001666 IEP
    long-chain fatty acid metabolic process GO:0001676 IBA
    long-chain fatty acid metabolic process GO:0001676 IDA
    long-chain fatty acid metabolic process GO:0001676 IEA
    long-chain fatty acid metabolic process GO:0001676 ISO
    neuroblast proliferation GO:0007405 IEA
    neuroblast proliferation GO:0007405 ISO
    response to nutrient GO:0007584 IEP
    lipid biosynthetic process GO:0008610 IEA
    phospholipid biosynthetic process GO:0008654 IMP
    response to gravity GO:0009629 IEP
    positive regulation of long-chain fatty acid import across plasma membrane GO:0010747 IMP
    positive regulation of neuron projection development GO:0010976 IMP
    fatty acid transport GO:0015908 IGI
    triglyceride biosynthetic process GO:0019432 IGI
    cellular response to insulin stimulus GO:0032869 IEP
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 IBA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 IGI
    response to steroid hormone GO:0048545 IEP
    neuron development GO:0048666 IEP
Subcellular Localization
    mitochondrial outer membrane GO:0005741 IEA
    peroxisomal membrane GO:0005778 IEA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 IBA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Acsl6 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Acsl6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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