Gene description for Plaa
Gene name phospholipase A2, activating protein
Gene symbol Plaa
Other names/aliases PLA2P
Plap
Species Rattus norvegicus
 Database cross references - Plaa
ExoCarta ExoCarta_116645
Vesiclepedia VP_116645
Entrez Gene 116645
UniProt P54319  
 Plaa identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Plaa
Molecular Function
    phospholipase A2 activator activity GO:0016005 ISO
    ubiquitin binding GO:0043130 IBA
Biological Process
    prostaglandin metabolic process GO:0006693 ISO
    prostaglandin metabolic process GO:0006693 ISS
    inflammatory response GO:0006954 ISO
    nervous system development GO:0007399 IEA
    ubiquitin recycling GO:0010992 IBA
    macroautophagy GO:0016236 ISO
    macroautophagy GO:0016236 ISS
    positive regulation of phospholipase A2 activity GO:0032430 ISO
    positive regulation of phospholipase A2 activity GO:0032430 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 ISO
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 ISS
    cellular response to lipopolysaccharide GO:0071222 ISO
    cellular response to lipopolysaccharide GO:0071222 ISS
    negative regulation of protein K63-linked ubiquitination GO:1900045 ISO
    negative regulation of protein K63-linked ubiquitination GO:1900045 ISS
    positive regulation of synaptic vesicle recycling GO:1903423 ISO
    positive regulation of synaptic vesicle recycling GO:1903423 ISS
    positive regulation of dendrite extension GO:1903861 ISO
    positive regulation of dendrite extension GO:1903861 ISS
    positive regulation of neuron migration GO:2001224 ISO
    positive regulation of neuron migration GO:2001224 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    synapse GO:0045202 ISO
    synapse GO:0045202 ISS
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Plaa in sEVs
1
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Plaa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plaa is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here