Gene description for S100a8
Gene name	S100 calcium binding protein A8
Gene symbol	S100a8
Other names/aliases	Mrp8
Species	Rattus norvegicus
Database cross references - S100a8
ExoCarta	ExoCarta_116547
Vesiclepedia	VP_116547
Entrez Gene	116547
UniProt	P50115
S100a8 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for S100a8

Molecular Function     calcium ion binding GO:0005509 IBA     antioxidant activity GO:0016209 IEA     calcium-dependent protein binding GO:0048306 IBA Biological Process     leukocyte migration involved in inflammatory response GO:0002523 IBA     leukocyte migration involved in inflammatory response GO:0002523 ISO     leukocyte migration involved in inflammatory response GO:0002523 ISS     chronic inflammatory response GO:0002544 IEP     peptide secretion GO:0002790 ISO     positive regulation of peptide secretion GO:0002793 ISO     autophagy GO:0006914 ISO     autophagy GO:0006914 ISS     apoptotic process GO:0006915 IEA     response to zinc ion GO:0010043 IEP     astrocyte development GO:0014002 ISO     peptidyl-cysteine S-nitrosylation GO:0018119 ISO     neutrophil chemotaxis GO:0030593 IBA     neutrophil chemotaxis GO:0030593 ISO     neutrophil chemotaxis GO:0030593 ISS     response to lipopolysaccharide GO:0032496 IBA     response to lipopolysaccharide GO:0032496 IEP     autocrine signaling GO:0035425 IGI     endothelial cell migration GO:0043542 IBA     innate immune response GO:0045087 IEA     response to ethanol GO:0045471 IEP     positive regulation of inflammatory response GO:0050729 ISO     positive regulation of inflammatory response GO:0050729 ISS     neutrophil aggregation GO:0070488 IBA     neutrophil aggregation GO:0070488 ISO     neutrophil aggregation GO:0070488 ISS     cellular oxidant detoxification GO:0098869 IEA     positive regulation of cysteine-type endopeptidase activity GO:2001056 ISO     positive regulation of cysteine-type endopeptidase activity GO:2001056 ISS     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISS Subcellular Localization     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     cytoplasm GO:0005737 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IEA     intermediate filament cytoskeleton GO:0045111 IEA     intermediate filament cytoskeleton GO:0045111 ISO     calprotectin complex GO:1990660 ISO