Gene description for Slc6a9
Gene name solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Gene symbol Slc6a9
Other names/aliases GLYT-1
GLYT-1b
Glyt1
Species Rattus norvegicus
 Database cross references - Slc6a9
ExoCarta ExoCarta_116509
Vesiclepedia VP_116509
Entrez Gene 116509
UniProt P28572  
 Slc6a9 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Slc6a9
Molecular Function
    amino acid:sodium symporter activity GO:0005283 IBA
    amino acid:sodium symporter activity GO:0005283 IEA
    protein binding GO:0005515 IPI
    glycine transmembrane transporter activity GO:0015187 IDA
    glycine transmembrane transporter activity GO:0015187 ISO
    glycine transmembrane transporter activity GO:0015187 TAS
    glycine:sodium symporter activity GO:0015375 IDA
    glycine:sodium symporter activity GO:0015375 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    neurotransmitter uptake GO:0001504 ISO
    amino acid transmembrane transport GO:0003333 IEA
    neurotransmitter transport GO:0006836 IEA
    glycine transport GO:0015816 ISO
    glycine transport GO:0015816 ISO
    sodium ion transmembrane transport GO:0035725 IBA
    sodium ion transmembrane transport GO:0035725 IEA
    positive regulation of hemoglobin biosynthetic process GO:0046985 ISO
    regulation of synaptic transmission, glycinergic GO:0060092 ISO
    regulation of synaptic transmission, glycinergic GO:0060092 ISS
    glycine secretion, neurotransmission GO:0061537 ISO
    positive regulation of heme biosynthetic process GO:0070455 ISO
    glycine import across plasma membrane GO:1903804 IBA
    glycine import across plasma membrane GO:1903804 IDA
    glycine import across plasma membrane GO:1903804 ISO
    negative regulation of NMDA glutamate receptor activity GO:1904782 ISO
Subcellular Localization
    endosome GO:0005768 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    basal plasma membrane GO:0009925 ISO
    postsynaptic density GO:0014069 IDA
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 ISO
    lateral plasma membrane GO:0016328 ISO
    synaptic vesicle membrane GO:0030672 IDA
    dense core granule GO:0031045 IDA
    asymmetric synapse GO:0032279 IDA
    presynaptic membrane GO:0042734 IDA
    postsynaptic membrane GO:0045211 IDA
    hippocampal mossy fiber to CA3 synapse GO:0098686 IDA
    parallel fiber to Purkinje cell synapse GO:0098688 IDA
 Experiment description of studies that identified Slc6a9 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 99
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc6a9
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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