Gene description for Adk
Gene name adenosine kinase
Gene symbol Adk
Other names/aliases 2310026J05Rik
5033405D03Rik
AI255373
AI987814
Ak
Species Mus musculus
 Database cross references - Adk
ExoCarta ExoCarta_11534
Vesiclepedia VP_11534
Entrez Gene 11534
UniProt P55264  
 Adk identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Adk
Molecular Function
    adenosine kinase activity GO:0004001 IBA
    adenosine kinase activity GO:0004001 IDA
    adenosine kinase activity GO:0004001 IMP
    adenosine kinase activity GO:0004001 ISO
    deoxyadenosine kinase activity GO:0004136 IMP
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    purine nucleobase metabolic process GO:0006144 IBA
    purine ribonucleoside salvage GO:0006166 IDA
    dATP biosynthetic process GO:0006175 IMP
    positive regulation of cardiac muscle hypertrophy GO:0010613 ISO
    GMP salvage GO:0032263 IDA
    positive regulation of T cell proliferation GO:0042102 ISO
    AMP salvage GO:0044209 IDA
    AMP salvage GO:0044209 IEA
    type B pancreatic cell proliferation GO:0044342 ISO
    adenosine metabolic process GO:0046085 ISO
    dAMP salvage GO:0106383 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Adk in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Adk
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adk is involved
PathwayEvidenceSource
Drug ADME IEA Reactome
Metabolism IEA Reactome
Metabolism of nucleotides IEA Reactome
Nucleotide salvage IEA Reactome
Purine salvage IEA Reactome
Ribavirin ADME IEA Reactome





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