Gene description for Dcun1d1
Gene name DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Gene symbol Dcun1d1
Other names/aliases Rp42
SCCRO
Tes3
pTes3
Species Mus musculus
 Database cross references - Dcun1d1
ExoCarta ExoCarta_114893
Vesiclepedia VP_114893
Entrez Gene 114893
UniProt Q9QZ73  
 Dcun1d1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dcun1d1
Molecular Function
    ubiquitin conjugating enzyme binding GO:0031624 IBA
    ubiquitin-like protein binding GO:0032182 IBA
    cullin family protein binding GO:0097602 IBA
    cullin family protein binding GO:0097602 ISO
    cullin family protein binding GO:0097602 ISS
Biological Process
    regulation of protein ubiquitination GO:0031396 ISO
    regulation of protein ubiquitination GO:0031396 ISS
    protein neddylation GO:0045116 IBA
    regulation of protein neddylation GO:2000434 ISO
    regulation of protein neddylation GO:2000434 ISS
    positive regulation of protein neddylation GO:2000436 ISO
    positive regulation of protein neddylation GO:2000436 ISS
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IBA
    ubiquitin ligase complex GO:0000151 ISO
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Dcun1d1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dcun1d1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dcun1d1 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Neddylation IEA Reactome
Post-translational protein modification IEA Reactome





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