Gene description for PGLYRP2
Gene name peptidoglycan recognition protein 2
Gene symbol PGLYRP2
Other names/aliases HMFT0141
PGLYRPL
PGRP-L
PGRPL
TAGL-like
tagL
tagL-alpha
tagl-beta
Species Homo sapiens
 Database cross references - PGLYRP2
ExoCarta ExoCarta_114770
Entrez Gene 114770
HGNC 30013
MIM 608199
UniProt Q96PD5  
 PGLYRP2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for PGLYRP2
Molecular Function
    zinc ion binding GO:0008270 IEA
    peptidoglycan binding GO:0042834 IDA
    N-acetylmuramoyl-L-alanine amidase activity GO:0008745 TAS
    peptidoglycan receptor activity GO:0016019 IDA
Biological Process
    growth of symbiont in host GO:0044117 IEA
    regulation of inflammatory response GO:0050727 IEA
    innate immune response GO:0045087 NAS
    peptide amidation GO:0001519 NAS
    detection of bacterium GO:0016045 IDA
    negative regulation of interferon-gamma production GO:0032689 IEA
    peptidoglycan catabolic process GO:0009253 IEA
    pattern recognition receptor signaling pathway GO:0002221 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    negative regulation of natural killer cell differentiation involved in immune response GO:0032827 IEA
Subcellular Localization
    membrane GO:0016020 NAS
    intracellular GO:0005622 NAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified PGLYRP2 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for PGLYRP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PGLYRP2 is involved
No pathways found





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