Gene description for Chrnb1
Gene name cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
Gene symbol Chrnb1
Other names/aliases Achr-2
Acrb
Species Mus musculus
 Database cross references - Chrnb1
ExoCarta ExoCarta_11443
Vesiclepedia VP_11443
Entrez Gene 11443
UniProt P09690  
 Chrnb1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Chrnb1
Molecular Function
    excitatory extracellular ligand-gated monoatomic ion channel activity GO:0005231 IBA
    protein binding GO:0005515 IPI
    channel activity GO:0015267 ISO
    ligand-gated monoatomic ion channel activity GO:0015276 ISO
    acetylcholine receptor activity GO:0015464 IBA
    acetylcholine receptor activity GO:0015464 IEA
    acetylcholine receptor activity GO:0015464 ISO
    acetylcholine-gated monoatomic cation-selective channel activity GO:0022848 IGI
    acetylcholine-gated monoatomic cation-selective channel activity GO:0022848 IGI
    acetylcholine-gated monoatomic cation-selective channel activity GO:0022848 ISO
    acetylcholine-gated monoatomic cation-selective channel activity GO:0022848 ISS
    acetylcholine binding GO:0042166 IMP
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IBA
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 ISO
Biological Process
    postsynaptic membrane organization GO:0001941 IEA
    postsynaptic membrane organization GO:0001941 ISO
    skeletal muscle contraction GO:0003009 ISO
    monoatomic cation transport GO:0006812 IEA
    monoatomic cation transport GO:0006812 ISO
    muscle contraction GO:0006936 IEA
    muscle contraction GO:0006936 ISO
    signal transduction GO:0007165 ISO
    chemical synaptic transmission GO:0007268 IBA
    synaptic transmission, cholinergic GO:0007271 IEA
    synaptic transmission, cholinergic GO:0007271 ISO
    neuromuscular synaptic transmission GO:0007274 IEA
    neuromuscular synaptic transmission GO:0007274 ISO
    monoatomic ion transmembrane transport GO:0034220 IBA
    monoatomic ion transmembrane transport GO:0034220 IEA
    behavioral response to nicotine GO:0035095 IEA
    behavioral response to nicotine GO:0035095 ISO
    regulation of membrane potential GO:0042391 IGI
    nervous system process GO:0050877 ISO
    membrane depolarization GO:0051899 IBA
    muscle cell development GO:0055001 IEA
    muscle cell development GO:0055001 ISO
    excitatory postsynaptic potential GO:0060079 IEA
    acetylcholine receptor signaling pathway GO:0095500 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    acetylcholine-gated channel complex GO:0005892 IBA
    acetylcholine-gated channel complex GO:0005892 IDA
    acetylcholine-gated channel complex GO:0005892 ISO
    neuromuscular junction GO:0031594 IDA
    neuromuscular junction GO:0031594 ISO
    neuron projection GO:0043005 IBA
    synapse GO:0045202 IBA
    synapse GO:0045202 ISO
    postsynaptic specialization membrane GO:0099634 IDA
 Experiment description of studies that identified Chrnb1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Chrnb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rapsn  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Chrnb1 is involved
No pathways found





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