Gene description for Ugt1a6
Gene name UDP glucuronosyltransferase 1 family, polypeptide A6
Gene symbol Ugt1a6
Other names/aliases UDPGT 1-6
Udpgt
Ugt1
Ugt1a7
Species Rattus norvegicus
 Database cross references - Ugt1a6
ExoCarta ExoCarta_113992
Vesiclepedia VP_113992
Entrez Gene 113992
UniProt P08430  
 Ugt1a6 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Ugt1a6
Molecular Function
    retinoic acid binding GO:0001972 ISO
    glucuronosyltransferase activity GO:0015020 IDA
    glucuronosyltransferase activity GO:0015020 IEA
    glucuronosyltransferase activity GO:0015020 ISO
    enzyme binding GO:0019899 IBA
    enzyme binding GO:0019899 ISO
    protein homodimerization activity GO:0042803 ISO
    protein-containing complex binding GO:0044877 IDA
    protein heterodimerization activity GO:0046982 ISO
Biological Process
    liver development GO:0001889 IEP
    xenobiotic metabolic process GO:0006805 ISO
    response to organic cyclic compound GO:0014070 IEP
    4-chlorobiphenyl metabolic process GO:0018880 IDA
    response to lipopolysaccharide GO:0032496 IEP
    cellular response to hormone stimulus GO:0032870 IEP
    response to peptide hormone GO:0043434 IEP
    cellular glucuronidation GO:0052695 IBA
    cellular glucuronidation GO:0052695 ISO
    cellular response to glucocorticoid stimulus GO:0071385 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    protein-containing complex GO:0032991 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Ugt1a6 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Ugt1a6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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