Gene description for Ces1d
Gene name carboxylesterase 1D
Gene symbol Ces1d
Other names/aliases Ces3
Species Rattus norvegicus
 Database cross references - Ces1d
ExoCarta ExoCarta_113902
Vesiclepedia VP_113902
Entrez Gene 113902
UniProt P16303  
 Ces1d identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Ces1d
Molecular Function
    sterol ester esterase activity GO:0004771 ISO
    sterol ester esterase activity GO:0004771 ISS
    triacylglycerol lipase activity GO:0004806 ISO
    triacylglycerol lipase activity GO:0004806 ISS
    fatty-acyl-ethyl-ester synthase activity GO:0030339 IEA
    all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity GO:0047376 IEA
    retinyl-palmitate esterase activity GO:0050253 IDA
    carboxylic ester hydrolase activity GO:0052689 IBA
    carboxylic ester hydrolase activity GO:0052689 IEA
    carboxylic ester hydrolase activity GO:0052689 ISO
    carboxylesterase activity GO:0106435 ISO
Biological Process
    retinoid metabolic process GO:0001523 TAS
    cholesterol biosynthetic process GO:0006695 ISO
    cholesterol metabolic process GO:0008203 ISO
    positive regulation of cholesterol efflux GO:0010875 ISO
    negative regulation of cholesterol storage GO:0010887 ISO
    lipid catabolic process GO:0016042 IBA
    lipid catabolic process GO:0016042 ISO
    short-chain fatty acid catabolic process GO:0019626 ISO
    epithelial cell differentiation GO:0030855 ISO
    very-low-density lipoprotein particle assembly GO:0034379 ISO
    retinol metabolic process GO:0042572 IEA
    cholesterol homeostasis GO:0042632 ISO
    reverse cholesterol transport GO:0043691 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    acylglycerol catabolic process GO:0046464 ISO
    acylglycerol catabolic process GO:0046464 ISS
    medium-chain fatty acid metabolic process GO:0051791 ISO
    circadian temperature homeostasis GO:0060086 ISO
    cytosolic lipolysis GO:0061725 ISO
    cellular response to cold GO:0070417 ISO
    regulation of bile acid biosynthetic process GO:0070857 ISO
    cellular response to cholesterol GO:0071397 ISO
    cellular response to low-density lipoprotein particle stimulus GO:0071404 ISO
    positive regulation of cholesterol metabolic process GO:0090205 ISO
    cold-induced thermogenesis GO:0106106 ISO
    regulation of bile acid secretion GO:0120188 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum lumen GO:0005788 IEA
    endoplasmic reticulum lumen GO:0005788 ISO
    endoplasmic reticulum lumen GO:0005788 ISS
    lipid droplet GO:0005811 IBA
    lipid droplet GO:0005811 ISO
    lipid droplet GO:0005811 ISS
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified Ces1d in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Ces1d
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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