Gene description for STX1B
Gene name syntaxin 1B
Gene symbol STX1B
Other names/aliases GEFSP9
STX1B1
STX1B2
Species Homo sapiens
 Database cross references - STX1B
ExoCarta ExoCarta_112755
Entrez Gene 112755
HGNC 18539
MIM 601485
UniProt P61266  
 STX1B identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for STX1B
Molecular Function
    protein domain specific binding GO:0019904 IEA
    protein kinase binding GO:0019901 ISS
    SNAP receptor activity GO:0005484 IBA
    SNARE binding GO:0000149 IBA
Biological Process
    synaptic vesicle fusion to presynaptic membrane GO:0031629 IBA
    synaptic vesicle docking GO:0016081 ISS
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 ISS
    regulation of synaptic vesicle priming GO:0010807 ISS
    positive regulation of neurotransmitter secretion GO:0001956 ISS
    vesicle docking GO:0048278 IBA
    regulation of gene expression GO:0010468 ISS
    exocytosis GO:0006887 IBA
    intracellular protein transport GO:0006886 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    membrane GO:0016020 ISS
    microtubule organizing center GO:0005815 IEA
    SNARE complex GO:0031201 IBA
    cytosol GO:0005829 TAS
    synaptic vesicle GO:0008021 IBA
    spindle GO:0005819 IEA
    integral component of membrane GO:0016021 IBA
    plasma membrane GO:0005886 TAS
    endomembrane system GO:0012505 IBA
 Experiment description of studies that identified STX1B in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for STX1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STXBP1 6812
Reconstituted Complex Homo sapiens
2 VAMP1 6843
Two-hybrid Homo sapiens
3 VAPB 9217
Reconstituted Complex Homo sapiens
4 VAMP2 6844
Two-hybrid Homo sapiens
5 SNAP23 8773
Reconstituted Complex Homo sapiens
6 UNC13B 10497
Two-hybrid Homo sapiens
7 VAMP8 8673
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which STX1B is involved
PathwayEvidenceSource
Toxicity of botulinum toxin type C (BoNT/C) TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here