Gene description for SLC35D2
Gene name solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
Gene symbol SLC35D2
Other names/aliases HFRC1
SQV7L
UGTrel8
hfrc
Species Homo sapiens
 Database cross references - SLC35D2
ExoCarta ExoCarta_11046
Vesiclepedia VP_11046
Entrez Gene 11046
HGNC 20799
MIM 609182
UniProt Q76EJ3  
 SLC35D2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
Neuroblastoma cells 25944692    
 Gene ontology annotations for SLC35D2
Molecular Function
    nucleotide-sugar transmembrane transporter activity GO:0005338 EXP
    nucleotide-sugar transmembrane transporter activity GO:0005338 NAS
    nucleotide-sugar transmembrane transporter activity GO:0005338 TAS
    UDP-glucuronic acid transmembrane transporter activity GO:0005461 IBA
    UDP-N-acetylglucosamine transmembrane transporter activity GO:0005462 IBA
    UDP-N-acetylgalactosamine transmembrane transporter activity GO:0005463 IBA
    antiporter activity GO:0015297 IBA
Biological Process
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IMP
    heparan sulfate proteoglycan biosynthetic process GO:0015012 TAS
    nucleotide-sugar transmembrane transport GO:0015780 IBA
    UDP-glucuronic acid transmembrane transport GO:0015787 IEA
    UDP-N-acetylgalactosamine transmembrane transport GO:0015789 IEA
    keratan sulfate biosynthetic process GO:0018146 TAS
    UDP-N-acetylglucosamine transmembrane transport GO:1990569 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified SLC35D2 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SLC35D2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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