Gene description for Glo1
Gene name glyoxalase 1
Gene symbol Glo1
Other names/aliases 0610009E22Rik
1110008E19Rik
2510049H23Rik
AW550643
GLY1
Glo-1
Glo-1r
Glo-1s
Glo1-r
Glo1-s
Qglo
Species Mus musculus
 Database cross references - Glo1
ExoCarta ExoCarta_109801
Vesiclepedia VP_109801
Entrez Gene 109801
UniProt Q9CPU0  
 Glo1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Glo1
Molecular Function
    lactoylglutathione lyase activity GO:0004462 IDA
    lactoylglutathione lyase activity GO:0004462 ISO
    lactoylglutathione lyase activity GO:0004462 ISS
    zinc ion binding GO:0008270 IDA
    zinc ion binding GO:0008270 ISO
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    glutathione metabolic process GO:0006749 IEA
    glutathione metabolic process GO:0006749 ISO
    methylglyoxal metabolic process GO:0009438 ISO
    methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0019243 IC
    osteoclast differentiation GO:0030316 IMP
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of apoptotic process GO:0043066 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Glo1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Glo1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Glo1 is involved
PathwayEvidenceSource
Aerobic respiration and respiratory electron transport IEA Reactome
Metabolism IEA Reactome
Pyruvate metabolism IEA Reactome





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