Gene description for Oxsr1
Gene name oxidative-stress responsive 1
Gene symbol Oxsr1
Other names/aliases 2210022N24Rik
2810422B09Rik
AI462649
AW209236
Osr1
mKIAA1101
Species Mus musculus
 Database cross references - Oxsr1
ExoCarta ExoCarta_108737
Vesiclepedia VP_108737
Entrez Gene 108737
UniProt Q6P9R2  
 Oxsr1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Oxsr1
Molecular Function
    magnesium ion binding GO:0000287 ISO
    magnesium ion binding GO:0000287 ISS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IGI
    protein serine/threonine kinase activity GO:0004674 ISO
    protein serine/threonine kinase activity GO:0004674 ISS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 ISO
    ATP binding GO:0005524 ISS
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 ISO
    protein phosphorylation GO:0006468 ISS
    cell volume homeostasis GO:0006884 IEA
    cell volume homeostasis GO:0006884 ISO
    response to oxidative stress GO:0006979 IDA
    signal transduction GO:0007165 ISO
    osmosensory signaling pathway GO:0007231 IEA
    osmosensory signaling pathway GO:0007231 ISO
    response to xenobiotic stimulus GO:0009410 IGI
    positive regulation of T cell chemotaxis GO:0010820 IBA
    positive regulation of T cell chemotaxis GO:0010820 IMP
    positive regulation of T cell chemotaxis GO:0010820 ISO
    peptidyl-threonine phosphorylation GO:0018107 IGI
    peptidyl-threonine phosphorylation GO:0018107 ISO
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 IGI
    intracellular signal transduction GO:0035556 ISO
    intracellular signal transduction GO:0035556 ISS
    chemokine (C-C motif) ligand 21 signaling pathway GO:0038116 IMP
    chemokine (C-X-C motif) ligand 12 signaling pathway GO:0038146 IEA
    chemokine (C-X-C motif) ligand 12 signaling pathway GO:0038146 ISO
    protein autophosphorylation GO:0046777 ISO
    protein autophosphorylation GO:0046777 ISS
    renal sodium ion absorption GO:0070294 IEA
    renal sodium ion absorption GO:0070294 ISO
    cellular hyperosmotic response GO:0071474 IBA
    cellular hyperosmotic response GO:0071474 IEA
    cellular hyperosmotic response GO:0071474 ISO
    cellular hypotonic response GO:0071476 IGI
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 IGI
    negative regulation of potassium ion transmembrane transport GO:1901380 IGI
    cellular response to chemokine GO:1990869 IMP
    cellular response to chemokine GO:1990869 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Oxsr1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Oxsr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg16l1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Oxsr1 is involved
No pathways found





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