Gene description for Rnh1
Gene name ribonuclease/angiogenin inhibitor 1
Gene symbol Rnh1
Other names/aliases AW546468
C80305
RNH
Species Mus musculus
 Database cross references - Rnh1
ExoCarta ExoCarta_107702
Vesiclepedia VP_107702
Entrez Gene 107702
UniProt Q91VI7  
 Rnh1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rnh1
Molecular Function
    ribonuclease inhibitor activity GO:0008428 IBA
    ribonuclease inhibitor activity GO:0008428 ISO
    ribonuclease inhibitor activity GO:0008428 ISS
Biological Process
    cell migration GO:0016477 IBA
    regulation of Arp2/3 complex-mediated actin nucleation GO:0034315 IBA
    regulation of angiogenesis GO:0045765 IBA
    regulation of angiogenesis GO:0045765 ISO
Subcellular Localization
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IBA
    lamellipodium GO:0030027 IBA
    angiogenin-PRI complex GO:0032311 IBA
    angiogenin-PRI complex GO:0032311 ISO
 Experiment description of studies that identified Rnh1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rnh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Ero1l 50527
Co-fractionation Mus musculus
3 Nphp4  
Affinity Capture-MS Mus musculus
4 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
5 Sdcbp 53378
Co-fractionation Mus musculus
6 Ptges3 56351
Co-fractionation Mus musculus
7 Nphp1  
Affinity Capture-MS Mus musculus
8 Iqcb1  
Affinity Capture-MS Mus musculus
9 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Rnh1 is involved
No pathways found





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