Gene description for Slc39a6
Gene name solute carrier family 39 (metal ion transporter), member 6
Gene symbol Slc39a6
Other names/aliases Ermelin
Species Mus musculus
 Database cross references - Slc39a6
ExoCarta ExoCarta_106957
Vesiclepedia VP_106957
Entrez Gene 106957
UniProt Q8C145  
 Slc39a6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc39a6
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 ISO
    zinc ion transmembrane transporter activity GO:0005385 ISS
    protein binding GO:0005515 IPI
    monoatomic cation:bicarbonate symporter activity GO:0140410 IBA
Biological Process
    epithelial to mesenchymal transition GO:0001837 IDA
    epithelial to mesenchymal transition GO:0001837 ISO
    intracellular zinc ion homeostasis GO:0006882 IEA
    intracellular zinc ion homeostasis GO:0006882 ISO
    intracellular monoatomic cation homeostasis GO:0030003 IBA
    lymphocyte activation GO:0046649 ISO
    lymphocyte activation GO:0046649 ISS
    T cell receptor signaling pathway GO:0050852 ISO
    T cell receptor signaling pathway GO:0050852 ISS
    zinc ion transmembrane transport GO:0071577 ISO
    zinc ion transmembrane transport GO:0071577 ISS
    zinc ion import across plasma membrane GO:0071578 IBA
    zinc ion import across plasma membrane GO:0071578 ISO
    zinc ion import across plasma membrane GO:0071578 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
    lamellipodium membrane GO:0031258 ISO
    lamellipodium membrane GO:0031258 ISS
    membrane raft GO:0045121 ISO
    membrane raft GO:0045121 ISS
 Experiment description of studies that identified Slc39a6 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc39a6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fitm2  
Negative Genetic Mus musculus
2 Atg12  
Negative Genetic Mus musculus
3 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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