Gene description for Trip10
Gene name thyroid hormone receptor interactor 10
Gene symbol Trip10
Other names/aliases AI646975
Cip4
Species Mus musculus
 Database cross references - Trip10
ExoCarta ExoCarta_106628
Vesiclepedia VP_106628
Entrez Gene 106628
UniProt Q8CJ53  
 Trip10 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Trip10
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    epithelial to mesenchymal transition GO:0001837 ISO
    endocytosis GO:0006897 IEA
    signal transduction GO:0007165 IEA
    negative regulation of cardiac muscle cell apoptotic process GO:0010667 ISO
    positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 ISO
Subcellular Localization
    phagocytic cup GO:0001891 IEA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    lysosome GO:0005764 IEA
    Golgi apparatus GO:0005794 IEA
    microtubule GO:0005874 TAS
    cell cortex GO:0005938 IEA
    cell projection GO:0042995 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Trip10 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Trip10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Wasf1  
Co-fractionation Mus musculus
2 Fnbp1  
Co-fractionation Mus musculus
3 Crebbp  
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
4 Wdr44  
Co-fractionation Mus musculus
View the network image/svg+xml



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