Gene description for POSTN
Gene name periostin, osteoblast specific factor
Gene symbol POSTN
Other names/aliases OSF-2
OSF2
PDLPOSTN
PN
periostin
Species Homo sapiens
 Database cross references - POSTN
ExoCarta ExoCarta_10631
Entrez Gene 10631
HGNC 16953
MIM 608777
UniProt Q15063  
 POSTN identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Prostate cancer cells 25844599    
 Gene ontology annotations for POSTN
Molecular Function
    heparin binding GO:0008201 ISS
    cell adhesion molecule binding GO:0050839 IBA
    protein binding GO:0005515 IPI
Biological Process
    regulation of Notch signaling pathway GO:0008593 IEA
    extracellular matrix organization GO:0030198 IBA
    cell adhesion GO:0007155 IDA
    skeletal system development GO:0001501 TAS
    tissue development GO:0009888 IEA
Subcellular Localization
    trans-Golgi network GO:0005802 IDA
    extracellular matrix GO:0031012 IDA
    extracellular space GO:0005615 IBA
    proteinaceous extracellular matrix GO:0005578 ISS
 Experiment description of studies that identified POSTN in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for POSTN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which POSTN is involved
No pathways found





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