Gene description for Akr1c18
Gene name aldo-keto reductase family 1, member C18
Gene symbol Akr1c18
Other names/aliases AW146047
Species Mus musculus
 Database cross references - Akr1c18
ExoCarta ExoCarta_105349
Vesiclepedia VP_105349
Entrez Gene 105349
UniProt Q8K023  
 Akr1c18 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Akr1c18
Molecular Function
    retinal dehydrogenase activity GO:0001758 ISO
    aldose reductase (NADPH) activity GO:0004032 IBA
    aldose reductase (NADPH) activity GO:0004032 IEA
    aldose reductase (NADPH) activity GO:0004032 ISO
    aldo-keto reductase (NADPH) activity GO:0004033 ISO
    all-trans-retinol dehydrogenase (NAD+) activity GO:0004745 ISO
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0016655 ISO
    testosterone dehydrogenase [NAD(P)+] activity GO:0030283 ISO
    bile acid binding GO:0032052 IBA
    geranylgeranyl reductase activity GO:0045550 ISO
    ketoreductase activity GO:0045703 ISO
    17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity GO:0047006 IDA
    17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity GO:0047006 IMP
    17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity GO:0047006 ISO
    15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity GO:0047020 ISO
    androsterone dehydrogenase activity GO:0047023 IBA
    androsterone dehydrogenase activity GO:0047023 ISO
    ketosteroid monooxygenase activity GO:0047086 IBA
    ketosteroid monooxygenase activity GO:0047086 ISO
    Delta4-3-oxosteroid 5beta-reductase activity GO:0047787 ISO
Biological Process
    prostaglandin metabolic process GO:0006693 IBA
    prostaglandin metabolic process GO:0006693 ISO
    progesterone catabolic process GO:0006709 IDA
    progesterone catabolic process GO:0006709 IMP
    G protein-coupled receptor signaling pathway GO:0007186 ISO
    female pregnancy GO:0007565 IEA
    parturition GO:0007567 IMP
    positive regulation of cell population proliferation GO:0008284 ISO
    farnesol catabolic process GO:0016488 ISO
    progesterone metabolic process GO:0042448 IBA
    progesterone metabolic process GO:0042448 ISO
    progesterone metabolic process GO:0042448 ISO
    retinal metabolic process GO:0042574 ISO
    daunorubicin metabolic process GO:0044597 IBA
    daunorubicin metabolic process GO:0044597 ISO
    doxorubicin metabolic process GO:0044598 IBA
    doxorubicin metabolic process GO:0044598 ISO
    regulation of retinoic acid receptor signaling pathway GO:0048385 ISO
    regulation of steroid biosynthetic process GO:0050810 IEA
    regulation of steroid biosynthetic process GO:0050810 ISO
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    testosterone biosynthetic process GO:0061370 ISO
    cellular response to calcium ion GO:0071277 ISO
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IEA
    cellular response to prostaglandin stimulus GO:0071379 ISO
    cellular response to corticosteroid stimulus GO:0071384 ISO
    cellular response to testosterone stimulus GO:0071394 IEA
    cellular response to jasmonic acid stimulus GO:0071395 ISO
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 ISO
    cellular response to prostaglandin D stimulus GO:0071799 ISO
    cellular response to gonadotropin-releasing hormone GO:0097211 IEA
    negative regulation of retinoic acid biosynthetic process GO:1900053 ISO
    cellular response to forskolin GO:1904322 IEA
    cellular response to prolactin GO:1990646 IEA
    regulation of testosterone biosynthetic process GO:2000224 ISO
    positive regulation of endothelial cell apoptotic process GO:2000353 ISO
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Akr1c18 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Akr1c18
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Akr1c18 is involved
No pathways found





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