Gene description for Blmh
Gene name bleomycin hydrolase
Gene symbol Blmh
Other names/aliases AI035728
Bh
Bmh
Species Mus musculus
 Database cross references - Blmh
ExoCarta ExoCarta_104184
Vesiclepedia VP_104184
Entrez Gene 104184
UniProt Q8R016  
 Blmh identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Blmh
Molecular Function
    aminopeptidase activity GO:0004177 IBA
    aminopeptidase activity GO:0004177 ISO
    cysteine-type endopeptidase activity GO:0004197 IEA
    peptidase activity GO:0008233 IMP
    cysteine-type peptidase activity GO:0008234 IBA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    cysteine-type aminopeptidase activity GO:0070005 IEA
Biological Process
    proteolysis GO:0006508 IEA
    response to xenobiotic stimulus GO:0009410 IMP
    response to toxic substance GO:0009636 IBA
    response to toxic substance GO:0009636 IMP
    homocysteine catabolic process GO:0043418 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Blmh in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Blmh
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sh3glb2  
Co-fractionation Mus musculus
2 Fancd2  
Affinity Capture-MS Mus musculus
3 Uba5  
Co-fractionation Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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