Gene description for Qsox1
Gene name quiescin Q6 sulfhydryl oxidase 1
Gene symbol Qsox1
Other names/aliases 1300003H02Rik
QSOX
Qscn6
SOx
Species Mus musculus
 Database cross references - Qsox1
ExoCarta ExoCarta_104009
Vesiclepedia VP_104009
Entrez Gene 104009
UniProt Q8BND5  
 Qsox1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Qsox1
Molecular Function
    protein disulfide isomerase activity GO:0003756 IBA
    protein disulfide isomerase activity GO:0003756 ISO
    protein disulfide isomerase activity GO:0003756 ISS
    flavin-dependent sulfhydryl oxidase activity GO:0016971 IBA
    flavin-dependent sulfhydryl oxidase activity GO:0016971 ISO
    flavin-dependent sulfhydryl oxidase activity GO:0016971 ISS
    FAD binding GO:0071949 IEA
    FAD binding GO:0071949 ISO
Biological Process
    protein folding GO:0006457 IBA
    negative regulation of macroautophagy GO:0016242 IEA
    negative regulation of macroautophagy GO:0016242 ISO
    extracellular matrix assembly GO:0085029 IEA
    extracellular matrix assembly GO:0085029 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    endoplasmic reticulum GO:0005783 ISO
    Golgi apparatus GO:0005794 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    intercellular bridge GO:0045171 IEA
    intercellular bridge GO:0045171 ISO
    extracellular exosome GO:0070062 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Qsox1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Qsox1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ubqln4  
Co-fractionation Mus musculus
View the network image/svg+xml



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