Gene description for RAPGEF2
Gene name Rap guanine nucleotide exchange factor (GEF) 2
Gene symbol RAPGEF2
Other names/aliases PDZ-GEF1
RA-GEF-1
nRap GEP
Species Bos taurus
 Database cross references - RAPGEF2
ExoCarta ExoCarta_100139484
Vesiclepedia VP_100139484
Entrez Gene 100139484
UniProt F1MSG6  
 RAPGEF2 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for RAPGEF2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
    protein binding GO:0005515 IEA
Biological Process
    small GTPase-mediated signal transduction GO:0007264 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
 Experiment description of studies that identified RAPGEF2 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAPGEF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RAPGEF2 is involved
PathwayEvidenceSource
MAPK family signaling cascades IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
RAF/MAP kinase cascade IEA Reactome
Signal Transduction IEA Reactome





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