Gene description for HSPA8
Gene name heat shock 70kDa protein 8
Gene symbol HSPA8
Other names/aliases -
Species Equus caballus
 Database cross references - HSPA8
ExoCarta ExoCarta_100009679
Vesiclepedia VP_100009679
Entrez Gene 100009679
UniProt None  
 HSPA8 identified in sEVs derived from the following tissue/cell type
Follicular fluid 22116803    
 Gene ontology annotations for HSPA8
Molecular Function
    ATP binding GO:0005524 IEA
    ATP-dependent protein folding chaperone GO:0140662 IEA
    clathrin-uncoating ATPase activity GO:1990833 IEA
Biological Process
    late endosomal microautophagy GO:0061738 IEA
    protein targeting to lysosome involved in chaperone-mediated autophagy GO:0061740 IEA
    clathrin coat disassembly GO:0072318 IEA
    chaperone-mediated autophagy translocation complex disassembly GO:1904764 IEA
    slow axonal transport GO:1990832 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    lysosome GO:0005764 IEA
    autophagosome GO:0005776 IEA
    plasma membrane GO:0005886 IEA
    dendrite GO:0030425 IEA
    terminal bouton GO:0043195 IEA
    presynaptic cytosol GO:0099523 IEA
    postsynaptic cytosol GO:0099524 IEA
 Experiment description of studies that identified HSPA8 in sEVs
1
Experiment ID 147
MISEV standards
EM
Biophysical techniques
HSP70|CD63
Enriched markers
cytochrome c
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 22116803    
Organism Equus caballus
Experiment description Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
Authors "da Silveira JC, Veeramachaneni DN, Winger QA, Carnevale EM, Bouma GJ"
Journal name Biol Reprod
Publication year 2011
Sample Follicular fluid
Sample name Follicular fluid - Ovarian - Young mare
Isolation/purification methods Differential centrifugation
Exoquick
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
RT-PCR
Mass spectrometry [LTQ]
 Protein-protein interactions for HSPA8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HSPA8 is involved
No pathways found





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