Gene description for ZNF254
Gene name zinc finger protein 254
Gene symbol ZNF254
Other names/aliases BMZF-5
HD-ZNF1
ZNF539
ZNF91L
Species Homo sapiens
 Database cross references - ZNF254
ExoCarta ExoCarta_9534
Vesiclepedia VP_9534
Entrez Gene 9534
HGNC 13047
MIM 604768
UniProt O75437  
 ZNF254 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for ZNF254
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified ZNF254 in sEVs
1
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZNF254
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF479  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CYP24A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LTBP2 4053
Affinity Capture-MS Homo sapiens
4 ADRB2  
Two-hybrid Homo sapiens
5 TRIM28 10155
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TRIM24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZNF467  
Affinity Capture-MS Homo sapiens
8 TRIM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF254 is involved
PathwayEvidenceSource
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
RNA Polymerase II Transcription TAS Reactome





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