Gene description for ACVRL1
Gene name activin A receptor type II-like 1
Gene symbol ACVRL1
Other names/aliases ACVRLK1
ALK-1
ALK1
HHT
HHT2
ORW2
SKR3
TSR-I
Species Homo sapiens
 Database cross references - ACVRL1
ExoCarta ExoCarta_94
Vesiclepedia VP_94
Entrez Gene 94
HGNC 175
MIM 601284
UniProt P37023  
 ACVRL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ACVRL1
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IDA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 NAS
    transforming growth factor beta receptor activity GO:0005024 IDA
    transforming growth factor beta receptor activity, type I GO:0005025 IBA
    transforming growth factor beta receptor activity, type I GO:0005025 IDA
    transforming growth factor beta receptor activity, type II GO:0005026 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    activin receptor activity, type I GO:0016361 IDA
    activin receptor activity, type II GO:0016362 IEA
    protein kinase binding GO:0019901 IPI
    SMAD binding GO:0046332 IBA
    SMAD binding GO:0046332 IDA
    metal ion binding GO:0046872 IEA
    activin binding GO:0048185 IDA
    transforming growth factor beta binding GO:0050431 IPI
    transforming growth factor beta receptor activity, type III GO:0070123 IEA
    BMP receptor activity GO:0098821 IDA
    BMP receptor activity GO:0098821 IGI
    BMP receptor activity GO:0098821 IMP
Biological Process
    angiogenesis GO:0001525 IBA
    angiogenesis GO:0001525 IMP
    response to hypoxia GO:0001666 IEA
    in utero embryonic development GO:0001701 IEA
    regulation of endothelial cell proliferation GO:0001936 TAS
    negative regulation of endothelial cell proliferation GO:0001937 IEA
    positive regulation of endothelial cell proliferation GO:0001938 IEA
    lymphangiogenesis GO:0001946 ISS
    blood vessel maturation GO:0001955 TAS
    blood vessel remodeling GO:0001974 ISS
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 TAS
    endocardial cushion morphogenesis GO:0003203 ISS
    regulation of DNA replication GO:0006275 TAS
    regulation of DNA-templated transcription GO:0006355 IMP
    negative regulation of cell adhesion GO:0007162 IMP
    signal transduction GO:0007165 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    heart development GO:0007507 IBA
    blood circulation GO:0008015 IMP
    regulation of blood pressure GO:0008217 IMP
    negative regulation of cell population proliferation GO:0008285 IMP
    dorsal/ventral pattern formation GO:0009953 IBA
    negative regulation of endothelial cell migration GO:0010596 IDA
    negative regulation of gene expression GO:0010629 ISS
    cell differentiation GO:0030154 IBA
    negative regulation of cell growth GO:0030308 IDA
    negative regulation of cell migration GO:0030336 IMP
    BMP signaling pathway GO:0030509 IBA
    BMP signaling pathway GO:0030509 IDA
    BMP signaling pathway GO:0030509 IGI
    BMP signaling pathway GO:0030509 IMP
    BMP signaling pathway GO:0030509 TAS
    positive regulation of BMP signaling pathway GO:0030513 IDA
    positive regulation of epithelial cell differentiation GO:0030858 IGI
    positive regulation of chondrocyte differentiation GO:0032332 TAS
    activin receptor signaling pathway GO:0032924 IEA
    wound healing, spreading of epidermal cells GO:0035313 IMP
    dorsal aorta morphogenesis GO:0035912 ISS
    regulation of blood vessel endothelial cell migration GO:0043535 TAS
    negative regulation of blood vessel endothelial cell migration GO:0043537 IMP
    negative regulation of endothelial cell differentiation GO:0045602 IEA
    positive regulation of endothelial cell differentiation GO:0045603 IEA
    positive regulation of Notch signaling pathway GO:0045747 IGI
    positive regulation of angiogenesis GO:0045766 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    negative regulation of focal adhesion assembly GO:0051895 IMP
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    lymphatic endothelial cell differentiation GO:0060836 IMP
    artery development GO:0060840 ISS
    venous blood vessel development GO:0060841 ISS
    endothelial tube morphogenesis GO:0061154 IMP
    retina vasculature development in camera-type eye GO:0061298 ISS
    cellular response to growth factor stimulus GO:0071363 IBA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    cellular response to BMP stimulus GO:0071773 IMP
    endocardial cushion to mesenchymal transition GO:0090500 ISS
    positive regulation of bicellular tight junction assembly GO:1903348 IGI
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IDA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    BMP receptor complex GO:0070724 IBA
 Experiment description of studies that identified ACVRL1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ACVRL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGSF1  
Affinity Capture-Western Homo sapiens
2 BAMBI  
Reconstituted Complex Homo sapiens
3 ACVR1 90
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TGFBR1 7046
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 SMAD1 4086
Biochemical Activity Homo sapiens
6 SLC25A24 29957
Affinity Capture-MS Homo sapiens
7 PDXDC2P  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TSC22D1 8848
Affinity Capture-Western Homo sapiens
9 GDF2 2658
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
10 TGFB1 7040
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
12 INHBA 3624
Affinity Capture-Western Homo sapiens
13 SNX6 58533
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ACVRL1 is involved
PathwayEvidenceSource
Signal Transduction TAS Reactome
Signaling by BMP TAS Reactome
Signaling by TGFB family members TAS Reactome





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