Gene description for HIST1H2AM
Gene name histone cluster 1, H2am
Gene symbol HIST1H2AM
Other names/aliases H2A.1
H2A/n
H2AFN
dJ193B12.1
Species Homo sapiens
 Database cross references - HIST1H2AM
ExoCarta ExoCarta_8336
Vesiclepedia VP_8336
Entrez Gene 8336
HGNC 4735
MIM 602796
UniProt P0C0S8  
 HIST1H2AM identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
 Gene ontology annotations for HIST1H2AM
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    structural constituent of chromatin GO:0030527 IBA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    heterochromatin formation GO:0031507 IBA
Subcellular Localization
    nucleosome GO:0000786 IBA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HIST1H2AM in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
3
Experiment ID 140
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
4
Experiment ID 141
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
5
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
6
Experiment ID 144
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
7
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
8
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for HIST1H2AM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 NOP14 8602
Affinity Capture-MS Homo sapiens
3 UTP18  
Affinity Capture-MS Homo sapiens
4 SENP3 26168
Affinity Capture-MS Homo sapiens
5 RPL26L1 51121
Affinity Capture-MS Homo sapiens
6 MRPL48  
Affinity Capture-MS Homo sapiens
7 PPAN-P2RY11  
Affinity Capture-MS Homo sapiens
8 KNOP1 400506
Affinity Capture-MS Homo sapiens
9 DDX24 57062
Affinity Capture-MS Homo sapiens
10 RPS20 6224
Affinity Capture-MS Homo sapiens
11 ARID5B 84159
Affinity Capture-MS Homo sapiens
12 AATF  
Affinity Capture-MS Homo sapiens
13 ZNF346  
Affinity Capture-MS Homo sapiens
14 MRPL17  
Affinity Capture-MS Homo sapiens
15 RPS17 6218
Affinity Capture-MS Homo sapiens
16 XPC  
Affinity Capture-MS Homo sapiens
17 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
18 SDAD1  
Affinity Capture-MS Homo sapiens
19 EPB41L5 57669
Affinity Capture-MS Homo sapiens
20 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
21 RPS19 6223
Affinity Capture-MS Homo sapiens
22 SMARCA1 6594
Affinity Capture-MS Homo sapiens
23 EPB41L4B 54566
Affinity Capture-MS Homo sapiens
24 MRPL27 51264
Affinity Capture-MS Homo sapiens
25 DHX57 90957
Affinity Capture-MS Homo sapiens
26 RSBN1  
Affinity Capture-MS Homo sapiens
27 MRPS27 23107
Affinity Capture-MS Homo sapiens
28 ZBTB11  
Affinity Capture-MS Homo sapiens
29 RPS3 6188
Affinity Capture-MS Homo sapiens
30 MRPS18C  
Affinity Capture-MS Homo sapiens
31 MRPS5 64969
Affinity Capture-MS Homo sapiens
32 XRCC1 7515
Affinity Capture-MS Homo sapiens
33 MRPS10 55173
Affinity Capture-MS Homo sapiens
34 RPS2 6187
Affinity Capture-MS Homo sapiens
35 SART3 9733
Affinity Capture-MS Homo sapiens
36 MCM2 4171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 HIST1H2BD 3017
Affinity Capture-MS Homo sapiens
38 CCDC137  
Affinity Capture-MS Homo sapiens
39 RRP12 23223
Affinity Capture-MS Homo sapiens
40 COPS5 10987
Affinity Capture-MS Homo sapiens
41 MRPS24 64951
Affinity Capture-MS Homo sapiens
42 PRPF4B 8899
Affinity Capture-MS Homo sapiens
43 KRI1  
Affinity Capture-MS Homo sapiens
44 RPS5 6193
Affinity Capture-MS Homo sapiens
45 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
46 MRPS26 64949
Affinity Capture-MS Homo sapiens
47 HELZ2  
Affinity Capture-MS Homo sapiens
48 ZCCHC3  
Affinity Capture-MS Homo sapiens
49 STAU2 27067
Affinity Capture-MS Homo sapiens
50 PRKRA 8575
Affinity Capture-MS Homo sapiens
51 XRN1 54464
Affinity Capture-MS Homo sapiens
52 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
53 SRP68 6730
Affinity Capture-MS Homo sapiens
54 NOC3L 64318
Affinity Capture-MS Homo sapiens
55 NAP1L4 4676
Affinity Capture-MS Homo sapiens
56 MRPS7 51081
Affinity Capture-MS Homo sapiens
57 WIZ 58525
Affinity Capture-MS Homo sapiens
58 POP1 10940
Affinity Capture-MS Homo sapiens
59 FAM111A 63901
Affinity Capture-MS Homo sapiens
60 CUL1 8454
Affinity Capture-MS Homo sapiens
61 SETD1A 9739
Affinity Capture-MS Homo sapiens
62 OASL 8638
Affinity Capture-MS Homo sapiens
63 NEDD8 4738
Affinity Capture-MS Homo sapiens
64 SREK1 140890
Affinity Capture-MS Homo sapiens
65 HIST2H4A 8370
Affinity Capture-MS Homo sapiens
66 CTCF  
Affinity Capture-MS Homo sapiens
67 RBM19 9904
Affinity Capture-MS Homo sapiens
68 CCDC86  
Affinity Capture-MS Homo sapiens
69 ZCRB1  
Affinity Capture-MS Homo sapiens
70 RPS4Y2 140032
Affinity Capture-MS Homo sapiens
71 MRPL13  
Affinity Capture-MS Homo sapiens
72 FARS2 10667
Affinity Capture-MS Homo sapiens
73 EIF2AK2 5610
Affinity Capture-MS Homo sapiens
74 DDX31  
Affinity Capture-MS Homo sapiens
75 CDKN2AIP  
Affinity Capture-MS Homo sapiens
76 SCAF1  
Affinity Capture-MS Homo sapiens
77 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
78 DDX21 9188
Affinity Capture-MS Homo sapiens
79 CUL4B 8450
Affinity Capture-MS Homo sapiens
80 KRR1 11103
Affinity Capture-MS Homo sapiens
81 RBM28 55131
Affinity Capture-MS Homo sapiens
82 RPS10 6204
Affinity Capture-MS Homo sapiens
83 PHF14 9678
Affinity Capture-MS Homo sapiens
84 YBX2 51087
Affinity Capture-MS Homo sapiens
85 BLM 641
Affinity Capture-MS Homo sapiens
86 MRPS11  
Affinity Capture-MS Homo sapiens
87 STAU1 6780
Affinity Capture-MS Homo sapiens
88 PTCD1 26024
Affinity Capture-MS Homo sapiens
89 CFDP1  
Affinity Capture-MS Homo sapiens
90 PTCD3 55037
Affinity Capture-MS Homo sapiens
91 PAK1IP1  
Affinity Capture-MS Homo sapiens
92 MKRN4P  
Affinity Capture-MS Homo sapiens
93 DDX10  
Affinity Capture-MS Homo sapiens
94 ANKHD1 54882
Affinity Capture-MS Homo sapiens
95 SRBD1  
Affinity Capture-MS Homo sapiens
96 NKRF 55922
Affinity Capture-MS Homo sapiens
97 NOC4L 79050
Affinity Capture-MS Homo sapiens
98 NCL 4691
Affinity Capture-MS Homo sapiens
99 ASCC2 84164
Affinity Capture-MS Homo sapiens
100 MRPS9 64965
Affinity Capture-MS Homo sapiens
101 MRPL3  
Affinity Capture-MS Homo sapiens
102 NGDN  
Affinity Capture-MS Homo sapiens
103 HIST1H2BK 85236
Affinity Capture-MS Homo sapiens
104 PELP1 27043
Affinity Capture-MS Homo sapiens
105 H2AFY 9555
Affinity Capture-MS Homo sapiens
106 PPM1G 5496
Affinity Capture-MS Homo sapiens
107 GTPBP4 23560
Affinity Capture-MS Homo sapiens
108 MRPS33  
Affinity Capture-MS Homo sapiens
109 IPO9 55705
Affinity Capture-MS Homo sapiens
110 MGMT 4255
Affinity Capture-MS Homo sapiens
111 RPF1  
Affinity Capture-MS Homo sapiens
112 LARP1 23367
Affinity Capture-MS Homo sapiens
113 ELAVL2 1993
Affinity Capture-MS Homo sapiens
114 TPX2  
Affinity Capture-MS Homo sapiens
115 TONSL  
Affinity Capture-MS Homo sapiens
116 MIER3 166968
Affinity Capture-MS Homo sapiens
117 MIER1  
Affinity Capture-MS Homo sapiens
118 MRPL40 64976
Affinity Capture-MS Homo sapiens
119 BMS1  
Affinity Capture-MS Homo sapiens
120 SPATS2L 26010
Affinity Capture-MS Homo sapiens
121 RPLP2 6181
Affinity Capture-MS Homo sapiens
122 ABT1 29777
Affinity Capture-MS Homo sapiens
123 MRPL15 29088
Affinity Capture-MS Homo sapiens
124 DAP3 7818
Affinity Capture-MS Homo sapiens
125 CHERP 10523
Affinity Capture-MS Homo sapiens
126 BAZ1B 9031
Affinity Capture-MS Homo sapiens
127 MRPS35 60488
Affinity Capture-MS Homo sapiens
128 YTHDC2 64848
Affinity Capture-MS Homo sapiens
129 TUBA8 51807
Affinity Capture-MS Homo sapiens
130 NAT10 55226
Affinity Capture-MS Homo sapiens
131 RLIM 51132
Affinity Capture-MS Homo sapiens
132 MRPL9 65005
Affinity Capture-MS Homo sapiens
133 SRSF5 6430
Affinity Capture-MS Homo sapiens
134 RPL3 6122
Affinity Capture-MS Homo sapiens
135 TRIM41 90933
Affinity Capture-MS Homo sapiens
136 ZC3H8  
Affinity Capture-MS Homo sapiens
137 GADD45GIP1  
Affinity Capture-MS Homo sapiens
138 RSL24D1  
Affinity Capture-MS Homo sapiens
139 NAP1L1 4673
Affinity Capture-MS Homo sapiens
140 NIP7 51388
Affinity Capture-MS Homo sapiens
141 HIST1H2BO 8348
Affinity Capture-MS Homo sapiens
142 CAND1 55832
Affinity Capture-MS Homo sapiens
143 CDYL 9425
Affinity Capture-MS Homo sapiens
144 BUD13  
Affinity Capture-MS Homo sapiens
145 DKC1 1736
Affinity Capture-MS Homo sapiens
146 CMSS1  
Affinity Capture-MS Homo sapiens
147 SS18L2  
Affinity Capture-MS Homo sapiens
148 PRKRIR  
Affinity Capture-MS Homo sapiens
149 LTV1  
Affinity Capture-MS Homo sapiens
150 DHX30 22907
Affinity Capture-MS Homo sapiens
151 PHF6  
Affinity Capture-MS Homo sapiens
152 RPS14 6208
Affinity Capture-MS Homo sapiens
153 EHMT2 10919
Affinity Capture-MS Homo sapiens
154 DDX54 79039
Affinity Capture-MS Homo sapiens
155 CRAMP1L 57585
Affinity Capture-MS Homo sapiens
156 MMS22L  
Affinity Capture-MS Homo sapiens
157 PCGF1 84759
Affinity Capture-MS Homo sapiens
158 MAK16  
Affinity Capture-MS Homo sapiens
159 FYTTD1  
Affinity Capture-MS Homo sapiens
160 NOP16 51491
Affinity Capture-MS Homo sapiens
161 CETN2 1069
Affinity Capture-MS Homo sapiens
162 HMG20A  
Affinity Capture-MS Homo sapiens
163 MRPL47 57129
Affinity Capture-MS Homo sapiens
164 APLF  
Affinity Capture-MS Homo sapiens
165 FTSJ3 117246
Affinity Capture-MS Homo sapiens
166 SUPT16H 11198
Affinity Capture-MS Homo sapiens
167 DDX55  
Affinity Capture-MS Homo sapiens
168 RPS3A 6189
Affinity Capture-MS Homo sapiens
169 RPS16 6217
Affinity Capture-MS Homo sapiens
170 U2SURP 23350
Affinity Capture-MS Homo sapiens
171 FAM120A 23196
Affinity Capture-MS Homo sapiens
172 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
173 YBX1 4904
Affinity Capture-MS Homo sapiens
174 DDX50 79009
Affinity Capture-MS Homo sapiens
175 SURF6  
Affinity Capture-MS Homo sapiens
176 DIS3L2 129563
Affinity Capture-MS Homo sapiens
177 DHX36 170506
Affinity Capture-MS Homo sapiens
178 TOE1 114034
Affinity Capture-MS Homo sapiens
179 PARP1 142
Affinity Capture-MS Homo sapiens
180 LIG3 3980
Affinity Capture-MS Homo sapiens
181 ILF3 3609
Affinity Capture-RNA Homo sapiens
182 RPLP0 6175
Affinity Capture-MS Homo sapiens
183 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
184 GAR1 54433
Affinity Capture-MS Homo sapiens
185 UBE2O 63893
Affinity Capture-MS Homo sapiens
186 PRDM15  
Affinity Capture-MS Homo sapiens
187 COQ6 51004
Affinity Capture-MS Homo sapiens
188 NOL10  
Affinity Capture-MS Homo sapiens
189 MRPS31  
Affinity Capture-MS Homo sapiens
190 SRSF12  
Affinity Capture-MS Homo sapiens
191 CUL5 8065
Affinity Capture-MS Homo sapiens
192 HLTF  
Affinity Capture-MS Homo sapiens
193 MRPL28 10573
Affinity Capture-MS Homo sapiens
194 RPS15 6209
Affinity Capture-MS Homo sapiens
195 MRPS15  
Affinity Capture-MS Homo sapiens
196 SRP72 6731
Affinity Capture-MS Homo sapiens
197 GON4L  
Affinity Capture-MS Homo sapiens
198 HDAC1 3065
Affinity Capture-MS Homo sapiens
199 CHD1L 9557
Affinity Capture-MS Homo sapiens
200 NSA2  
Affinity Capture-MS Homo sapiens
201 DDX58 23586
Affinity Capture-RNA Homo sapiens
202 NIFK 84365
Affinity Capture-MS Homo sapiens
203 PARP2  
Affinity Capture-MS Homo sapiens
204 GPATCH4 54865
Affinity Capture-MS Homo sapiens
205 DDX27 55661
Affinity Capture-MS Homo sapiens
206 RPS28 6234
Affinity Capture-MS Homo sapiens
207 LARP7 51574
Affinity Capture-MS Homo sapiens
208 NOC2L 26155
Affinity Capture-MS Homo sapiens
209 MRPS18B 28973
Affinity Capture-MS Homo sapiens
210 MOV10 4343
Affinity Capture-MS Homo sapiens
211 H2AFZ 3015
Affinity Capture-MS Homo sapiens
212 YBX3 8531
Affinity Capture-MS Homo sapiens
213 ZNF768 79724
Affinity Capture-MS Homo sapiens
214 CUL4A 8451
Affinity Capture-MS Homo sapiens
215 EHMT1  
Affinity Capture-MS Homo sapiens
216 RPL23A 6147
Affinity Capture-MS Homo sapiens
217 APOBEC3F 200316
Affinity Capture-MS Homo sapiens
218 MRPS25 64432
Affinity Capture-MS Homo sapiens
219 RPL36AL 6166
Affinity Capture-MS Homo sapiens
220 TRIM29 23650
Affinity Capture-MS Homo sapiens
221 SSRP1 6749
Affinity Capture-MS Homo sapiens
222 PURA 5813
Affinity Capture-MS Homo sapiens
223 TEX10 54881
Affinity Capture-MS Homo sapiens
224 C16orf87 388272
Affinity Capture-MS Homo sapiens
225 C11orf31  
Affinity Capture-MS Homo sapiens
226 DDX56  
Affinity Capture-MS Homo sapiens
227 ZSCAN25  
Affinity Capture-MS Homo sapiens
228 RPL17 6139
Affinity Capture-MS Homo sapiens
229 IMP4  
Affinity Capture-MS Homo sapiens
230 PARN  
Affinity Capture-MS Homo sapiens
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