Gene description for Ptgr1
Gene name prostaglandin reductase 1
Gene symbol Ptgr1
Other names/aliases 2510002C21Rik
Ltb4dh
Zadh3
Species Mus musculus
 Database cross references - Ptgr1
ExoCarta ExoCarta_67103
Vesiclepedia VP_67103
Entrez Gene 67103
UniProt Q91YR9  
 Ptgr1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ptgr1
Molecular Function
    2-alkenal reductase (NADPH) activity GO:0035798 ISO
    2-alkenal reductase (NADPH) activity GO:0035798 ISS
    13-lipoxin reductase activity GO:0036185 ISS
    15-oxoprostaglandin 13-oxidase [NAD(P)+] activity GO:0047522 IBA
    15-oxoprostaglandin 13-oxidase [NAD(P)+] activity GO:0047522 ISO
    15-oxoprostaglandin 13-oxidase [NAD(P)+] activity GO:0047522 ISS
    leukotriene B4 12-hydroxy dehydrogenase activity GO:0097257 ISS
Biological Process
    prostaglandin metabolic process GO:0006693 IBA
    prostaglandin metabolic process GO:0006693 ISO
    prostaglandin metabolic process GO:0006693 ISS
    leukotriene B4 metabolic process GO:0036102 ISO
    leukotriene B4 metabolic process GO:0036102 ISS
    alkene metabolic process GO:0043449 ISO
    negative regulation of positive chemotaxis GO:0050928 ISO
    negative regulation of reactive oxygen species biosynthetic process GO:1903427 ISO
    lipoxin A4 metabolic process GO:2001302 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Ptgr1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ptgr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptgr1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here