Gene description for SIGLEC1
Gene name sialic acid binding Ig-like lectin 1, sialoadhesin
Gene symbol SIGLEC1
Other names/aliases CD169
SIGLEC-1
SN
dJ1009E24.1
Species Homo sapiens
 Database cross references - SIGLEC1
ExoCarta ExoCarta_6614
Vesiclepedia VP_6614
Entrez Gene 6614
HGNC 11127
MIM 600751
UniProt Q9BZZ2  
 SIGLEC1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SIGLEC1
Molecular Function
    carbohydrate binding GO:0030246 NAS
    virion binding GO:0046790 IBA
Biological Process
    inflammatory response GO:0006954 NAS
    cell-matrix adhesion GO:0007160 NAS
    negative regulation of type I interferon production GO:0032480 IDA
    clathrin-dependent endocytosis of virus by host cell GO:0075512 IBA
    cell-cell adhesion GO:0098609 NAS
Subcellular Localization
    extracellular region GO:0005576 IEA
    early endosome GO:0005769 IBA
    late endosome GO:0005770 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 NAS
 Experiment description of studies that identified SIGLEC1 in sEVs
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SIGLEC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRD3 8019
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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