Gene description for BMP5
Gene name bone morphogenetic protein 5
Gene symbol BMP5
Other names/aliases -
Species Homo sapiens
 Database cross references - BMP5
ExoCarta ExoCarta_653
Vesiclepedia VP_653
Entrez Gene 653
HGNC 1072
MIM 112265
UniProt P22003  
 BMP5 identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for BMP5
Molecular Function
    cytokine activity GO:0005125 IBA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    BMP receptor binding GO:0070700 IDA
Biological Process
    skeletal system development GO:0001501 NAS
    ossification GO:0001503 IEA
    endocardial cushion formation GO:0003272 ISS
    type B pancreatic cell development GO:0003323 IDA
    pericardium morphogenesis GO:0003344 ISS
    pattern specification process GO:0007389 IEA
    positive regulation of cell population proliferation GO:0008284 IDA
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of epithelial to mesenchymal transition GO:0010719 NAS
    negative regulation of steroid biosynthetic process GO:0010894 IDA
    neural fold elevation formation GO:0021502 ISS
    BMP signaling pathway GO:0030509 IDA
    male genitalia development GO:0030539 IEA
    hindbrain development GO:0030902 ISS
    negative regulation of aldosterone biosynthetic process GO:0032348 IDA
    negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 IDA
    ear development GO:0043583 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    cardiac muscle tissue development GO:0048738 ISS
    positive regulation of epithelial cell proliferation GO:0050679 IDA
    cartilage development GO:0051216 IEA
    pharyngeal system development GO:0060037 ISS
    positive regulation of SMAD protein signal transduction GO:0060391 IDA
    cardiac septum morphogenesis GO:0060411 ISS
    chorio-allantoic fusion GO:0060710 ISS
    heart trabecula morphogenesis GO:0061384 ISS
    negative regulation of mononuclear cell migration GO:0071676 NAS
    anterior head development GO:0097065 IEA
    positive regulation of dendrite development GO:1900006 IDA
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 NAS
    allantois development GO:1905069 ISS
    negative regulation of cortisol biosynthetic process GO:2000065 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISS
    vesicle GO:0031982 ISS
 Experiment description of studies that identified BMP5 in sEVs
1
Experiment ID 497
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BMP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANKRD46 157567
Affinity Capture-MS Homo sapiens
2 HBB 3043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MEOX2  
Two-hybrid Homo sapiens
4 VWA8 23078
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BMP5 is involved
No pathways found





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