Gene description for DMRTA1
Gene name DMRT-like family A1
Gene symbol DMRTA1
Other names/aliases DMO
DMRT4
Species Homo sapiens
 Database cross references - DMRTA1
ExoCarta ExoCarta_63951
Vesiclepedia VP_63951
Entrez Gene 63951
HGNC 13826
MIM 614803
UniProt Q5VZB9  
 DMRTA1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DMRTA1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IEA
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    ovarian follicle development GO:0001541 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    sex differentiation GO:0007548 IBA
    male mating behavior GO:0060179 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified DMRTA1 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DMRTA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
2 ORC5  
Two-hybrid Homo sapiens
3 STAT5B 6777
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DMRTA1 is involved
No pathways found





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