Gene description for RGS10
Gene name regulator of G-protein signaling 10
Gene symbol RGS10
Other names/aliases -
Species Homo sapiens
 Database cross references - RGS10
ExoCarta ExoCarta_6001
Vesiclepedia VP_6001
Entrez Gene 6001
HGNC 9992
MIM 602856
UniProt O43665  
 RGS10 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for RGS10
Molecular Function
    G-protein alpha-subunit binding GO:0001965 IPI
    GTPase activity GO:0003924 TAS
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    G protein-coupled acetylcholine receptor signaling pathway GO:0007213 IDA
    regulation of G protein-coupled receptor signaling pathway GO:0008277 IEA
    negative regulation of signal transduction GO:0009968 IEA
    positive regulation of GTPase activity GO:0043547 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 TAS
    nuclear body GO:0016604 IDA
    synapse GO:0045202 IEA
 Experiment description of studies that identified RGS10 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RGS10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 IL1R2  
Affinity Capture-MS Homo sapiens
3 DNAJB6 10049
Affinity Capture-MS Homo sapiens
4 ADRB2  
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
5 GNAZ 2781
Affinity Capture-Western Homo sapiens
6 SAP18 10284
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 EIF6 3692
Affinity Capture-MS Homo sapiens
8 PLEKHF2 79666
Two-hybrid Homo sapiens
9 BBS1 582
Affinity Capture-MS Homo sapiens
10 ACP6 51205
Affinity Capture-MS Homo sapiens
11 GNAI3 2773
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
12 GNAI1 2770
Reconstituted Complex Homo sapiens
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