Gene description for CTDSP1
Gene name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Gene symbol CTDSP1
Other names/aliases NIF3
NLI-IF
NLIIF
SCP1
Species Homo sapiens
 Database cross references - CTDSP1
ExoCarta ExoCarta_58190
Vesiclepedia VP_58190
Entrez Gene 58190
HGNC 21614
MIM 605323
UniProt Q9GZU7  
 CTDSP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CTDSP1
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II CTD heptapeptide repeat phosphatase activity GO:0008420 IBA
    RNA polymerase II CTD heptapeptide repeat phosphatase activity GO:0008420 IDA
    myosin phosphatase activity GO:0017018 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    metal ion binding GO:0046872 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    protein dephosphorylation GO:0006470 IDA
    negative regulation of neuron differentiation GO:0045665 IEA
    negative regulation of neurogenesis GO:0050768 IEA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CTDSP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTDSP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 MORN3  
Two-hybrid Homo sapiens
3 HEATR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RAMP3  
Affinity Capture-MS Homo sapiens
5 C8orf76  
Affinity Capture-MS Homo sapiens
6 C1orf86  
Two-hybrid Homo sapiens
7 FBXL22  
Affinity Capture-MS Homo sapiens
8 SDCBP 6386
Two-hybrid Homo sapiens
9 CRYBA2  
Two-hybrid Homo sapiens
10 ABCB6 10058
Affinity Capture-MS Homo sapiens
11 MCAM 4162
Proximity Label-MS Homo sapiens
12 SNAI1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
13 BAG3 9531
Two-hybrid Homo sapiens
14 LAMP3  
Proximity Label-MS Homo sapiens
15 XPO1 7514
Affinity Capture-MS Homo sapiens
16 CDCA3 83461
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CSTF2T  
Two-hybrid Homo sapiens
18 IGFBP3 3486
Affinity Capture-MS Homo sapiens
19 SCNM1  
Two-hybrid Homo sapiens
20 HMGCL 3155
Affinity Capture-MS Homo sapiens
21 DSTYK 25778
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 NOXA1  
Two-hybrid Homo sapiens
23 TEKT4  
Two-hybrid Homo sapiens
24 FANCL 55120
Two-hybrid Homo sapiens
25 TUBB1 81027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ATP12A 479
Affinity Capture-MS Homo sapiens
28 TIMM10  
Affinity Capture-MS Homo sapiens
29 MAPKBP1  
Two-hybrid Homo sapiens
30 LAMP2 3920
Proximity Label-MS Homo sapiens
31 TAB2  
Affinity Capture-MS Homo sapiens
32 WWOX 51741
Two-hybrid Homo sapiens
33 LIPK  
Affinity Capture-MS Homo sapiens
34 ZBTB16  
Two-hybrid Homo sapiens
35 ACTN3 89
Two-hybrid Homo sapiens
36 FAM110A  
Two-hybrid Homo sapiens
37 MORF4L1  
Affinity Capture-MS Homo sapiens
38 LPCAT2 54947
Affinity Capture-MS Homo sapiens
39 POLR2A 5430
Biochemical Activity Homo sapiens
40 REST 5978
Affinity Capture-Western Homo sapiens
41 TBCD 6904
Affinity Capture-MS Homo sapiens
42 YPEL5 51646
Two-hybrid Homo sapiens
43 PRKAG1 5571
Affinity Capture-MS Homo sapiens
44 FGFR2 2263
Two-hybrid Homo sapiens
45 TOMM22 56993
Affinity Capture-MS Homo sapiens
46 STX17 55014
Affinity Capture-MS Homo sapiens
47 AGPAT6 137964
Affinity Capture-MS Homo sapiens
48 TYRO3 7301
Two-hybrid Homo sapiens
49 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TUBA1A 7846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 DNAJC5 80331
Affinity Capture-MS Homo sapiens
52 CTDSP2 10106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SLC25A6 293
Affinity Capture-MS Homo sapiens
54 FAM118B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 TUBA1C 84790
Affinity Capture-MS Homo sapiens
56 SLC25A4 291
Affinity Capture-MS Homo sapiens
57 CYBA 1535
Affinity Capture-MS Homo sapiens
58 ATP1A3 478
Affinity Capture-MS Homo sapiens
59 MBP 4155
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
60 CENPM  
Affinity Capture-MS Homo sapiens
61 OSTF1 26578
Two-hybrid Homo sapiens
62 STRA8  
Two-hybrid Homo sapiens
63 EPHA2 1969
Proximity Label-MS Homo sapiens
64 RAB3IL1 5866
Two-hybrid Homo sapiens
65 ITPKB  
Two-hybrid Homo sapiens
66 PPP1R32  
Two-hybrid Homo sapiens
67 SLC20A1 6574
Affinity Capture-MS Homo sapiens
68 RHOB 388
Proximity Label-MS Homo sapiens
69 FANCI 55215
Affinity Capture-MS Homo sapiens
70 SLC22A4 6583
Affinity Capture-MS Homo sapiens
71 PEX3 8504
Affinity Capture-MS Homo sapiens
72 NOP10 55505
Affinity Capture-MS Homo sapiens
73 CSF1R  
Two-hybrid Homo sapiens
74 CTDSPL 10217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 KRTAP6-1  
Affinity Capture-MS Homo sapiens
76 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
77 CDKN2C  
Two-hybrid Homo sapiens
78 LCK 3932
Two-hybrid Homo sapiens
79 LYPLAL1 127018
Affinity Capture-MS Homo sapiens
80 USP22 23326
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CTDSP1 is involved
No pathways found





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