Gene description for Park7
Gene name Parkinson disease (autosomal recessive, early onset) 7
Gene symbol Park7
Other names/aliases DJ-1
Dj1
Species Mus musculus
 Database cross references - Park7
ExoCarta ExoCarta_57320
Vesiclepedia VP_57320
Entrez Gene 57320
UniProt Q99LX0  
 Park7 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Park7
Molecular Function
    transcription coactivator activity GO:0003713 IEA
    transcription coactivator activity GO:0003713 ISO
    RNA binding GO:0003723 TAS
    mRNA binding GO:0003729 ISO
    mRNA binding GO:0003729 ISS
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    copper ion binding GO:0005507 ISO
    copper ion binding GO:0005507 ISS
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 ISO
    peptidase activity GO:0008233 ISS
    superoxide dismutase copper chaperone activity GO:0016532 IEA
    superoxide dismutase copper chaperone activity GO:0016532 ISO
    oxidoreductase activity, acting on peroxide as acceptor GO:0016684 IBA
    oxidoreductase activity, acting on peroxide as acceptor GO:0016684 ISO
    oxygen sensor activity GO:0019826 IMP
    enzyme binding GO:0019899 ISO
    kinase binding GO:0019900 IEA
    kinase binding GO:0019900 ISO
    cytokine binding GO:0019955 IEA
    cytokine binding GO:0019955 ISO
    peptidase inhibitor activity GO:0030414 IEA
    signaling receptor activator activity GO:0030546 IEA
    tyrosine 3-monooxygenase activator activity GO:0036470 IEA
    tyrosine 3-monooxygenase activator activity GO:0036470 ISO
    L-dopa decarboxylase activator activity GO:0036478 IEA
    L-dopa decarboxylase activator activity GO:0036478 ISO
    protein deglycase activity GO:0036524 ISO
    protein deglycase activity GO:0036524 ISS
    protein deglycase activity GO:0036524 ISS
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    small protein activating enzyme binding GO:0044388 IEA
    small protein activating enzyme binding GO:0044388 ISO
    ubiquitin-like protein conjugating enzyme binding GO:0044390 IEA
    ubiquitin-like protein conjugating enzyme binding GO:0044390 ISO
    protein-containing complex binding GO:0044877 ISO
    mercury ion binding GO:0045340 ISO
    mercury ion binding GO:0045340 ISS
    nuclear androgen receptor binding GO:0050681 IEA
    nuclear androgen receptor binding GO:0050681 ISO
    peroxiredoxin activity GO:0051920 IMP
    ubiquitin-protein transferase inhibitor activity GO:0055105 ISS
    scaffold protein binding GO:0097110 IEA
    scaffold protein binding GO:0097110 ISO
    DNA-binding transcription factor binding GO:0140297 ISO
    cupric ion binding GO:1903135 IEA
    cupric ion binding GO:1903135 ISO
    cuprous ion binding GO:1903136 IEA
    cuprous ion binding GO:1903136 ISO
    ubiquitin-specific protease binding GO:1990381 IEA
    ubiquitin-specific protease binding GO:1990381 ISO
    glyoxalase (glycolic acid-forming) activity GO:1990422 ISO
    glyoxalase (glycolic acid-forming) activity GO:1990422 ISS
Biological Process
    negative regulation of protein phosphorylation GO:0001933 ISO
    synaptic transmission, dopaminergic GO:0001963 IMP
    positive regulation of acute inflammatory response to antigenic stimulus GO:0002866 IMP
    DNA repair GO:0006281 ISO
    DNA repair GO:0006281 ISS
    negative regulation of protein kinase activity GO:0006469 ISO
    proteolysis GO:0006508 IEA
    protein deglycosylation GO:0006517 ISO
    autophagy GO:0006914 IEA
    inflammatory response GO:0006954 IEA
    response to oxidative stress GO:0006979 IBA
    response to oxidative stress GO:0006979 IMP
    response to oxidative stress GO:0006979 ISO
    mitochondrion organization GO:0007005 IMP
    single fertilization GO:0007338 IEA
    adult locomotory behavior GO:0008344 IMP
    methylglyoxal metabolic process GO:0009438 ISO
    methylglyoxal metabolic process GO:0009438 ISS
    detoxification of copper ion GO:0010273 IMP
    detoxification of copper ion GO:0010273 ISO
    detoxification of copper ion GO:0010273 ISS
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of gene expression GO:0010629 ISO
    negative regulation of smooth muscle cell migration GO:0014912 ISO
    lactate biosynthetic process GO:0019249 IEA
    lactate biosynthetic process GO:0019249 ISO
    removal of superoxide radicals GO:0019430 IEA
    insulin secretion GO:0030073 IMP
    protein repair GO:0030091 IEA
    androgen receptor signaling pathway GO:0030521 IEA
    positive regulation of protein-containing complex assembly GO:0031334 IEA
    positive regulation of protein-containing complex assembly GO:0031334 ISO
    negative regulation of protein ubiquitination GO:0031397 IMP
    negative regulation of protein ubiquitination GO:0031397 ISO
    negative regulation of protein binding GO:0032091 ISO
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IEA
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISO
    positive regulation of interleukin-8 production GO:0032757 IEA
    positive regulation of interleukin-8 production GO:0032757 ISO
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    negative regulation of protein sumoylation GO:0033234 IEA
    negative regulation of protein sumoylation GO:0033234 ISO
    positive regulation of NAD(P)H oxidase activity GO:0033864 IMP
    cellular response to oxidative stress GO:0034599 IMP
    cellular response to oxidative stress GO:0034599 ISO
    cellular response to reactive oxygen species GO:0034614 IMP
    cellular response to glyoxal GO:0036471 IMP
    cellular response to glyoxal GO:0036471 ISO
    peptidyl-cysteine deglycation GO:0036526 ISO
    peptidyl-arginine deglycation GO:0036527 ISO
    peptidyl-lysine deglycation GO:0036528 ISO
    protein deglycation, glyoxal removal GO:0036529 ISO
    protein deglycation, methylglyoxal removal GO:0036530 ISO
    negative regulation of protein catabolic process GO:0042177 IMP
    response to hydrogen peroxide GO:0042542 IDA
    response to hydrogen peroxide GO:0042542 IMP
    glucose homeostasis GO:0042593 IMP
    hydrogen peroxide metabolic process GO:0042743 IMP
    hydrogen peroxide metabolic process GO:0042743 ISO
    regulation of neuron apoptotic process GO:0043523 ISO
    regulation of neuron apoptotic process GO:0043523 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    glycolate biosynthetic process GO:0046295 IBA
    glycolate biosynthetic process GO:0046295 IDA
    glycolate biosynthetic process GO:0046295 ISO
    negative regulation of protein export from nucleus GO:0046826 IEA
    negative regulation of protein export from nucleus GO:0046826 ISO
    regulation of inflammatory response GO:0050727 IMP
    detoxification of mercury ion GO:0050787 IMP
    detoxification of mercury ion GO:0050787 ISO
    protein stabilization GO:0050821 IMP
    protein stabilization GO:0050821 ISO
    protein stabilization GO:0050821 ISS
    positive regulation of DNA-binding transcription factor activity GO:0051091 ISO
    negative regulation of ubiquitin-protein transferase activity GO:0051444 ISO
    dopamine uptake involved in synaptic transmission GO:0051583 IMP
    regulation of mitochondrial membrane potential GO:0051881 IEA
    regulation of mitochondrial membrane potential GO:0051881 ISO
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    membrane depolarization GO:0051899 IMP
    membrane hyperpolarization GO:0060081 IMP
    regulation of androgen receptor signaling pathway GO:0060765 IEA
    regulation of androgen receptor signaling pathway GO:0060765 ISO
    detoxification of hydrogen peroxide GO:0061691 IEA
    detoxification of hydrogen peroxide GO:0061691 ISO
    methylglyoxal catabolic process to lactate GO:0061727 ISO
    methylglyoxal catabolic process to lactate GO:0061727 ISS
    cellular response to hydrogen peroxide GO:0070301 IEA
    cellular response to hydrogen peroxide GO:0070301 ISO
    detection of oxidative stress GO:0070994 IMP
    guanine deglycation GO:0106044 ISO
    guanine deglycation GO:0106044 ISS
    guanine deglycation, methylglyoxal removal GO:0106045 ISO
    guanine deglycation, methylglyoxal removal GO:0106045 ISS
    guanine deglycation, glyoxal removal GO:0106046 ISO
    guanine deglycation, glyoxal removal GO:0106046 ISS
    cellular detoxification of aldehyde GO:0110095 ISO
    cellular detoxification of aldehyde GO:0110095 ISS
    cellular detoxification of methylglyoxal GO:0140041 ISO
    cellular detoxification of methylglyoxal GO:0140041 ISS
    positive regulation of protein localization to nucleus GO:1900182 IEA
    positive regulation of protein localization to nucleus GO:1900182 ISO
    regulation of synaptic vesicle endocytosis GO:1900242 IDA
    regulation of synaptic vesicle endocytosis GO:1900242 IMP
    positive regulation of superoxide dismutase activity GO:1901671 ISO
    negative regulation of protein acetylation GO:1901984 IEA
    negative regulation of protein acetylation GO:1901984 ISO
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 IMP
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISO
    positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 IMP
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IMP
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 ISO
    positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 IMP
    positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 ISO
    negative regulation of death-inducing signaling complex assembly GO:1903073 IEA
    negative regulation of protein K48-linked deubiquitination GO:1903094 IEA
    negative regulation of protein K48-linked deubiquitination GO:1903094 ISO
    negative regulation of TRAIL-activated apoptotic signaling pathway GO:1903122 IEA
    negative regulation of TRAIL-activated apoptotic signaling pathway GO:1903122 ISO
    positive regulation of pyrroline-5-carboxylate reductase activity GO:1903168 ISO
    positive regulation of tyrosine 3-monooxygenase activity GO:1903178 ISO
    positive regulation of dopamine biosynthetic process GO:1903181 IEA
    positive regulation of dopamine biosynthetic process GO:1903181 ISO
    glyoxal metabolic process GO:1903189 IBA
    glyoxal metabolic process GO:1903189 IDA
    glyoxal metabolic process GO:1903189 ISO
    glyoxal catabolic process GO:1903190 IEA
    positive regulation of L-dopa biosynthetic process GO:1903197 IEA
    positive regulation of L-dopa biosynthetic process GO:1903197 ISO
    positive regulation of L-dopa decarboxylase activity GO:1903200 ISO
    regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903376 ISO
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 IMP
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 ISO
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway GO:1903384 IMP
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway GO:1903384 ISO
    negative regulation of reactive oxygen species biosynthetic process GO:1903427 IMP
    positive regulation of reactive oxygen species biosynthetic process GO:1903428 IDA
    negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:1903751 IMP
    negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:1903751 ISO
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 ISO
    negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway GO:1905259 IEA
    negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway GO:1905259 ISO
    positive regulation of fertilization GO:1905516 ISO
    negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO
    negative regulation of ubiquitin-specific protease activity GO:2000157 ISO
    positive regulation of oxidative phosphorylation uncoupler activity GO:2000277 IMP
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
    positive regulation of transcription regulatory region DNA binding GO:2000679 ISO
    positive regulation of androgen receptor activity GO:2000825 ISO
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
Subcellular Localization
    chromatin GO:0000785 IEA
    chromatin GO:0000785 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrial matrix GO:0005759 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 ISO
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    synaptic vesicle GO:0008021 IDA
    synaptic vesicle GO:0008021 IMP
    PML body GO:0016605 IEA
    PML body GO:0016605 ISO
    axon GO:0030424 ISO
    neuron projection GO:0043005 IDA
    cell body GO:0044297 IDA
    membrane raft GO:0045121 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    sperm head GO:0061827 ISO
 Experiment description of studies that identified Park7 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Park7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rab4a  
Co-fractionation Mus musculus
2 Cnksr2  
Affinity Capture-MS Mus musculus
3 Ndufb5  
Co-fractionation Mus musculus
4 Ndufa6  
Co-fractionation Mus musculus
5 Rab5b 19344
Co-fractionation Mus musculus
6 Tfe3  
Affinity Capture-MS Mus musculus
7 Trp53  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
8 Ndufa12  
Co-fractionation Mus musculus
9 Foxp3  
Affinity Capture-MS Mus musculus
10 Kctd13  
Affinity Capture-MS Mus musculus
11 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
12 5430435G22Rik  
Co-fractionation Mus musculus
13 Kcnma1  
Affinity Capture-MS Mus musculus
14 Ndufb6  
Co-fractionation Mus musculus
15 Map3k5  
Affinity Capture-Western Mus musculus
16 Tmem173  
Proximity Label-MS Mus musculus
17 Ret  
Phenotypic Enhancement Mus musculus
18 Unk  
Affinity Capture-RNA Mus musculus
19 Prkaca  
Affinity Capture-Western Mus musculus
20 Vamp2  
Affinity Capture-Western Mus musculus
21 Syp  
FRET Mus musculus
Affinity Capture-Western Mus musculus
22 Srebf2  
Affinity Capture-Western Mus musculus
23 Fancd2  
Affinity Capture-MS Mus musculus
24 Rab3a  
Co-fractionation Mus musculus
25 Tcf3  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here