Gene description for Trip4
Gene name thyroid hormone receptor interactor 4
Gene symbol Trip4
Other names/aliases 4930558E03Rik
ASC-1
Asc1
BB191711
Species Mus musculus
 Database cross references - Trip4
ExoCarta ExoCarta_56404
Vesiclepedia VP_56404
Entrez Gene 56404
UniProt Q9QXN3  
 Trip4 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trip4
Molecular Function
    protease binding GO:0002020 IEA
    protease binding GO:0002020 ISO
    transcription coactivator activity GO:0003713 ISO
    transcription coactivator activity GO:0003713 ISS
    zinc ion binding GO:0008270 IEA
    nuclear receptor binding GO:0016922 ISO
    nuclear receptor binding GO:0016922 ISS
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    nuclear estrogen receptor binding GO:0030331 ISO
    nuclear estrogen receptor binding GO:0030331 ISS
    histone acetyltransferase binding GO:0035035 ISO
    histone acetyltransferase binding GO:0035035 ISS
    ubiquitin-like protein ligase binding GO:0044389 ISO
    ubiquitin-like protein ligase binding GO:0044389 ISS
Biological Process
    regulation of DNA-templated transcription GO:0006355 ISO
    estrogen receptor signaling pathway GO:0030520 ISO
    estrogen receptor signaling pathway GO:0030520 ISS
    ribosome disassembly GO:0032790 ISO
    ribosome disassembly GO:0032790 ISS
    regulation of myoblast differentiation GO:0045661 IMP
    positive regulation of DNA-templated transcription GO:0045893 IBA
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of DNA-templated transcription GO:0045893 ISS
    rescue of stalled ribosome GO:0072344 ISO
    rescue of stalled ribosome GO:0072344 ISS
    ribosome-associated ubiquitin-dependent protein catabolic process GO:1990116 ISO
    ribosome-associated ubiquitin-dependent protein catabolic process GO:1990116 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    cytosol GO:0005829 IEA
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
    neuromuscular junction GO:0031594 ISO
    neuromuscular junction GO:0031594 ISS
    protein-containing complex GO:0032991 ISO
    activating signal cointegrator 1 complex GO:0099053 IEA
    activating signal cointegrator 1 complex GO:0099053 ISO
    RQC-trigger complex GO:0180022 IEA
 Experiment description of studies that identified Trip4 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trip4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nfe2  
Two-hybrid Mus musculus
2 Ewsr1 14030
Two-hybrid Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
4 Ubc  
Reconstituted Complex Mus musculus
5 Tcf3  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Trip4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here