Gene description for SUPT20H
Gene name suppressor of Ty 20 homolog (S. cerevisiae)
Gene symbol SUPT20H
Other names/aliases C13
C13orf19
FAM48A
FP757
P38IP
SPT20
Species Homo sapiens
 Database cross references - SUPT20H
ExoCarta ExoCarta_55578
Vesiclepedia VP_55578
Entrez Gene 55578
HGNC 20596
MIM 613417
UniProt Q8NEM7  
 SUPT20H identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for SUPT20H
Molecular Function
    transcription coregulator activity GO:0003712 IBA
    protein binding GO:0005515 IPI
Biological Process
    regulation of DNA repair GO:0006282 NAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    autophagy GO:0006914 IEA
    gastrulation GO:0007369 IEA
    regulation of RNA splicing GO:0043484 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
Subcellular Localization
    SAGA complex GO:0000124 IBA
    SAGA complex GO:0000124 NAS
    nucleus GO:0005634 IEA
    SAGA-type complex GO:0070461 IDA
 Experiment description of studies that identified SUPT20H in sEVs
1
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SUPT20H
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YEATS2  
Affinity Capture-MS Homo sapiens
2 CSRP2BP  
Affinity Capture-MS Homo sapiens
3 TADA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ATXN1 6310
Two-hybrid Homo sapiens
5 MECP2 4204
Affinity Capture-MS Homo sapiens
6 ENY2 56943
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KLF8  
Proximity Label-MS Homo sapiens
8 FASN 2194
Positive Genetic Homo sapiens
9 AQP2 359
Two-hybrid Homo sapiens
10 UBQLN4 56893
Two-hybrid Homo sapiens
11 FYN 2534
Affinity Capture-MS Homo sapiens
12 MAD2L1 4085
Affinity Capture-MS Homo sapiens
13 KAT2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FEV  
Proximity Label-MS Homo sapiens
15 KPNA1 3836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TRRAP 8295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ATG9A 79065
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 ATXN7L2  
Affinity Capture-MS Homo sapiens
19 MYLK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TADA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 JAZF1  
Proximity Label-MS Homo sapiens
22 ELK3  
Proximity Label-MS Homo sapiens
23 EDC4 23644
Affinity Capture-MS Homo sapiens
24 AURKA 6790
Reconstituted Complex Homo sapiens
25 NF2 4771
Negative Genetic Homo sapiens
26 KAT2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ATXN7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 DR1  
Affinity Capture-MS Homo sapiens
29 Mapk14  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
30 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
31 ZZZ3  
Affinity Capture-MS Homo sapiens
32 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
33 TAF10 6881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 WDR37 22884
Affinity Capture-MS Homo sapiens
35 SUPT7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MAPK1 5594
Two-hybrid Homo sapiens
37 DDX58 23586
Affinity Capture-RNA Homo sapiens
38 LDLRAD1  
Affinity Capture-MS Homo sapiens
39 ELF4 2000
Proximity Label-MS Homo sapiens
40 HIST3H3 8290
Protein-peptide Homo sapiens
41 SF3B5 83443
Affinity Capture-MS Homo sapiens
42 SOX4  
Proximity Label-MS Homo sapiens
43 TAF5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TAF9B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 MBIP  
Affinity Capture-MS Homo sapiens
46 LHX1  
Proximity Label-MS Homo sapiens
47 TAF9 6880
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 MYC  
Proximity Label-MS Homo sapiens
49 HECW2  
Affinity Capture-MS Homo sapiens
50 DYRK1A 1859
Affinity Capture-MS Homo sapiens
51 TAF12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PRAMEF9  
Affinity Capture-MS Homo sapiens
53 TADA2A  
Affinity Capture-MS Homo sapiens
54 SUPT3H  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CCDC101  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 KLF6  
Proximity Label-MS Homo sapiens
57 STAT3 6774
Two-hybrid Homo sapiens
58 ATXN7L3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 USP51  
Affinity Capture-MS Homo sapiens
60 MAPK14 1432
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
61 HS1BP3 64342
Affinity Capture-MS Homo sapiens
62 MAP3K7  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
63 TADA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PLAC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 MYCL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 SF3B3 23450
Affinity Capture-MS Homo sapiens
67 TAF6L 10629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 USP4 7375
Affinity Capture-Western Homo sapiens
69 USP27X  
Affinity Capture-MS Homo sapiens
70 RPA3 6119
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SUPT20H is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
HATs acetylate histones IEA Reactome





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