Gene description for PF4V1
Gene name platelet factor 4 variant 1
Gene symbol PF4V1
Other names/aliases CXCL4L1
CXCL4V1
PF4-ALT
PF4A
SCYB4V1
Species Homo sapiens
 Database cross references - PF4V1
ExoCarta ExoCarta_5197
Vesiclepedia VP_5197
Entrez Gene 5197
HGNC 8862
MIM 173461
UniProt P10720  
 PF4V1 identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for PF4V1
Molecular Function
    protein binding GO:0005515 IPI
    chemokine activity GO:0008009 IBA
    heparin binding GO:0008201 IEA
    CXCR chemokine receptor binding GO:0045236 IBA
Biological Process
    inflammatory response GO:0006954 IBA
    neutrophil chemotaxis GO:0030593 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA
    cellular response to lipopolysaccharide GO:0071222 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified PF4V1 in sEVs
1
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PF4V1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCL19  
Reconstituted Complex Homo sapiens
2 CXCL12 6387
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
3 ALB 213
Affinity Capture-MS Homo sapiens
4 CXCL10  
Reconstituted Complex Homo sapiens
5 CCL22 6367
Reconstituted Complex Homo sapiens
6 CCL11  
Reconstituted Complex Homo sapiens
7 CCL25  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 UBR1 197131
Affinity Capture-MS Homo sapiens
9 CXCL11  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
10 CCL28 56477
Reconstituted Complex Homo sapiens
11 CXCL13  
Reconstituted Complex Homo sapiens
12 CCL27  
Reconstituted Complex Homo sapiens
13 CCL4L1  
Reconstituted Complex Homo sapiens
14 XCL1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
15 XCL2  
Reconstituted Complex Homo sapiens
16 ATG9A 79065
Affinity Capture-MS Homo sapiens
17 CCL21  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
18 CCL26  
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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