Gene description for INPP5D
Gene name	inositol polyphosphate-5-phosphatase, 145kDa
Gene symbol	INPP5D
Other names/aliases	SHIP SHIP-1 SHIP1 SIP-145 hp51CN p150Ship
Species	Homo sapiens
Database cross references - INPP5D
ExoCarta	ExoCarta_3635
Vesiclepedia	VP_3635
Entrez Gene	3635
HGNC	6079
MIM	601582
UniProt	Q92835
INPP5D identified in sEVs derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for INPP5D

Molecular Function     phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IEA     inositol-polyphosphate 5-phosphatase activity GO:0004445 IDA     protein binding GO:0005515 IPI     phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0016314 TAS     SH3 domain binding GO:0017124 IEA     phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity GO:0034485 TAS     inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity GO:0052659 IEA Biological Process     phosphatidylinositol biosynthetic process GO:0006661 TAS     phosphate-containing compound metabolic process GO:0006796 TAS     apoptotic process GO:0006915 IEA     signal transduction GO:0007165 TAS     determination of adult lifespan GO:0008340 IEA     negative regulation of signal transduction GO:0009968 IBA     immunoglobulin mediated immune response GO:0016064 IEA     negative regulation of B cell proliferation GO:0030889 IEA     negative regulation of interleukin-6 production GO:0032715 IEA     intracellular signal transduction GO:0035556 IEA     positive regulation of apoptotic process GO:0043065 IEA     positive regulation of B cell differentiation GO:0045579 IBA     positive regulation of erythrocyte differentiation GO:0045648 IEA     negative regulation of monocyte differentiation GO:0045656 IEA     negative regulation of neutrophil differentiation GO:0045659 IBA     negative regulation of osteoclast differentiation GO:0045671 IEA     negative regulation of bone resorption GO:0045779 IBA     negative regulation of natural killer cell mediated cytotoxicity GO:0045953 IDA     phosphatidylinositol dephosphorylation GO:0046856 IEA     regulation of immune response GO:0050776 IBA     T cell receptor signaling pathway GO:0050852 TAS Subcellular Localization     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IEA     plasma membrane GO:0005886 IEA     membrane raft GO:0045121 IEA