Gene description for RHOA
Gene name ras homolog family member A
Gene symbol RHOA
Other names/aliases ARHA
Species Bos taurus
 Database cross references - RHOA
ExoCarta ExoCarta_338049
Vesiclepedia VP_338049
Entrez Gene 338049
UniProt P61585  
 RHOA identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for RHOA
Molecular Function
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IEA
Biological Process
    small GTPase-mediated signal transduction GO:0007264 IEA
    cell migration GO:0016477 IEA
    stress fiber assembly GO:0043149 IEA
Subcellular Localization
    cleavage furrow GO:0032154 IEA
    dendritic spine GO:0043197 IEA
 Experiment description of studies that identified RHOA in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RHOA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RHOA is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Axonal growth inhibition (RHOA activation) IEA Reactome
Axonal growth stimulation IEA Reactome
Beta-catenin independent WNT signaling IEA Reactome
Death Receptor Signaling IEA Reactome
Deubiquitination IEA Reactome
Developmental Biology IEA Reactome
EPH-Ephrin signaling IEA Reactome
EPHA-mediated growth cone collapse IEA Reactome
EPHB-mediated forward signaling IEA Reactome
ERBB2 Regulates Cell Motility IEA Reactome
G alpha (12/13) signalling events IEA Reactome
G beta:gamma signalling through PI3Kgamma IEA Reactome
G-protein beta:gamma signalling IEA Reactome
GPCR downstream signalling IEA Reactome
GPVI-mediated activation cascade IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Metabolism of proteins IEA Reactome
Nervous system development IEA Reactome
Neutrophil degranulation IEA Reactome
Ovarian tumor domain proteases IEA Reactome
p75 NTR receptor-mediated signalling IEA Reactome
p75NTR regulates axonogenesis IEA Reactome
PCP/CE pathway IEA Reactome
PI3K/AKT activation IEA Reactome
Platelet activation, signaling and aggregation IEA Reactome
Post-translational protein modification IEA Reactome
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases IEA Reactome
RHO GTPase cycle IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases activate CIT IEA Reactome
RHO GTPases Activate Formins IEA Reactome
RHO GTPases activate KTN1 IEA Reactome
RHO GTPases activate PKNs IEA Reactome
RHO GTPases Activate Rhotekin and Rhophilins IEA Reactome
RHO GTPases Activate ROCKs IEA Reactome
RHOA GTPase cycle IEA Reactome
RHOC GTPase cycle IEA Reactome
Sema4D in semaphorin signaling IEA Reactome
Sema4D induced cell migration and growth-cone collapse IEA Reactome
Sema4D mediated inhibition of cell attachment and migration IEA Reactome
Semaphorin interactions IEA Reactome
Signal Transduction IEA Reactome
Signaling by ERBB2 IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Non-Receptor Tyrosine Kinases IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by PTK6 IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by ROBO receptors IEA Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGFB family members IEA Reactome
Signaling by VEGF IEA Reactome
Signaling by WNT IEA Reactome
SLIT2:ROBO1 increases RHOA activity IEA Reactome
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IEA Reactome
VEGFA-VEGFR2 Pathway IEA Reactome





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