Gene description for PNPLA1
Gene name patatin-like phospholipase domain containing 1
Gene symbol PNPLA1
Other names/aliases ARCI10
dJ50J22.1
Species Homo sapiens
 Database cross references - PNPLA1
ExoCarta ExoCarta_285848
Vesiclepedia VP_285848
Entrez Gene 285848
HGNC 21246
MIM 612121
UniProt Q8N8W4  
 PNPLA1 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PNPLA1
Molecular Function
    triacylglycerol lipase activity GO:0004806 IBA
    acyltransferase activity, transferring groups other than amino-acyl groups GO:0016747 IMP
    structural constituent of skin epidermis GO:0030280 IC
    omega-hydroxyceramide transacylase activity GO:0106341 IDA
Biological Process
    triglyceride catabolic process GO:0019433 IBA
    ceramide biosynthetic process GO:0046513 IMP
    lipid homeostasis GO:0055088 IBA
    omega-hydroxyceramide biosynthetic process GO:0106342 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    lipid droplet GO:0005811 IBA
    membrane GO:0016020 IBA
 Experiment description of studies that identified PNPLA1 in sEVs
1
Experiment ID 211
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PNPLA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDCL 5082
Affinity Capture-MS Homo sapiens
2 ANKRD40 91369
Affinity Capture-MS Homo sapiens
3 TXNDC9 10190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UBR4 23352
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 METTL15  
Affinity Capture-MS Homo sapiens
6 CHMP3 51652
Affinity Capture-MS Homo sapiens
7 HBB 3043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 BIRC6 57448
Affinity Capture-MS Homo sapiens
9 PARP14 54625
Affinity Capture-MS Homo sapiens
10 TMEM160 54958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RNF123 63891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PDCL3 79031
Affinity Capture-MS Homo sapiens
14 UBAC1 10422
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 NIF3L1 60491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CCT6B 10693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CHMP1A 5119
Affinity Capture-MS Homo sapiens
18 UQCC1 55245
Affinity Capture-MS Homo sapiens
19 TCP1 6950
Affinity Capture-MS Homo sapiens
20 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PNPLA1 is involved
No pathways found





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